Naser Nazari, Mohammad Taghi Khodayari, Yazdan Hamzavi, Saber Raeghi, Seyed Ahmad Karamati, Shahab Falahi, Arezoo Bozorgomid, Mohammad Taha Sajedi
{"title":"基于血清学数据的猫作为中间宿主在犬新孢子虫生命周期中作用的系统评价和荟萃分析","authors":"Naser Nazari, Mohammad Taghi Khodayari, Yazdan Hamzavi, Saber Raeghi, Seyed Ahmad Karamati, Shahab Falahi, Arezoo Bozorgomid, Mohammad Taha Sajedi","doi":"10.1007/s11686-023-00661-6","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><p>Neosporosis is an important widespread parasitic infection caused by <i>N. caninum</i>. It infects a wide range of warm-blooded animals as intermediate hosts and dogs as the definitive host. Nevertheless, there are a number of questions regarding the life cycle and epidemiological aspects of <i>N. caninum</i>. Also, the role of felids (domestic and non-domestic) in the life cycle of <i>N. caninum</i> has been little described. Therefore, this study was conducted to evaluate the global prevalence of <i>N. caninum</i> in domestic and wild felids.</p><h3>Methods</h3><p>PubMed, Scopus, Google Scholar, Web of Science, and ScienceDirect databases were searched for articles published on the prevalence of <i>N. caninum</i> in felids until Aprill 2, 2022 and the reference lists of retrieved articles were screened. A random-effects meta-analysis model was used to estimate the pooled prevalence and 95% confidence interval. Heterogeneity among studies was evaluated using Cochran’s Q and the <i>I</i><sup>2</sup> statistic.</p><h3>Results</h3><p>After exclusion of irrelevant articles and duplication removal, 30 studies were eligible for quantitative analysis including 20 studies on domestic cats and 10 studies on wild felids. The overall prevalence of neosporosis infection in cats was 15% (95% CI 10–21%) that was significantly higher in wild felids (26%, 95% CI 13–38%) than in domestic cats (11%, 95% CI 6–16%) (<i>P</i> = 0.03). There was no significant difference in pooled prevalence between male and female domestic cats (<i>P</i> = 0.75). Regarding continent, the lowest prevalence of neosporosis infection was in Asia (9%, 95% CI 1–20%) and the highest was in North America (43.6%, 95% CI 33.9–53.2%) and Africa (18%, 95% CI 9–46%). Higher prevalence was obtained when using the NAT with 22% (95% CI 7–37%), compared to the IFAT (17%, 95% CI 9–24%) and ELISA (6%, 95% CI 2–9%) (<i>P</i> = 0.01).</p><h3>Conclusion</h3><p>The findings highlighted the importance of felids as potential intermediate hosts of neosporosis despite the fact that the source of the parasite for these animals was unknown. Further studies should be performed to investigate the role of this top predator (felids) in maintaining both domestic and sylvatic cycles of <i>Neospora caninum.</i></p></div>","PeriodicalId":6932,"journal":{"name":"Acta Parasitologica","volume":"68 1","pages":"266 - 276"},"PeriodicalIF":1.2000,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Systematic Review and Meta-analysis of Role of Felids as Intermediate Hosts in the Life Cycle of Neospora caninum Based on Serological Data\",\"authors\":\"Naser Nazari, Mohammad Taghi Khodayari, Yazdan Hamzavi, Saber Raeghi, Seyed Ahmad Karamati, Shahab Falahi, Arezoo Bozorgomid, Mohammad Taha Sajedi\",\"doi\":\"10.1007/s11686-023-00661-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Purpose</h3><p>Neosporosis is an important widespread parasitic infection caused by <i>N. caninum</i>. It infects a wide range of warm-blooded animals as intermediate hosts and dogs as the definitive host. Nevertheless, there are a number of questions regarding the life cycle and epidemiological aspects of <i>N. caninum</i>. Also, the role of felids (domestic and non-domestic) in the life cycle of <i>N. caninum</i> has been little described. Therefore, this study was conducted to evaluate the global prevalence of <i>N. caninum</i> in domestic and wild felids.</p><h3>Methods</h3><p>PubMed, Scopus, Google Scholar, Web of Science, and ScienceDirect databases were searched for articles published on the prevalence of <i>N. caninum</i> in felids until Aprill 2, 2022 and the reference lists of retrieved articles were screened. A random-effects meta-analysis model was used to estimate the pooled prevalence and 95% confidence interval. Heterogeneity among studies was evaluated using Cochran’s Q and the <i>I</i><sup>2</sup> statistic.</p><h3>Results</h3><p>After exclusion of irrelevant articles and duplication removal, 30 studies were eligible for quantitative analysis including 20 studies on domestic cats and 10 studies on wild felids. The overall prevalence of neosporosis infection in cats was 15% (95% CI 10–21%) that was significantly higher in wild felids (26%, 95% CI 13–38%) than in domestic cats (11%, 95% CI 6–16%) (<i>P</i> = 0.03). There was no significant difference in pooled prevalence between male and female domestic cats (<i>P</i> = 0.75). Regarding continent, the lowest prevalence of neosporosis infection was in Asia (9%, 95% CI 1–20%) and the highest was in North America (43.6%, 95% CI 33.9–53.2%) and Africa (18%, 95% CI 9–46%). Higher prevalence was obtained when using the NAT with 22% (95% CI 7–37%), compared to the IFAT (17%, 95% CI 9–24%) and ELISA (6%, 95% CI 2–9%) (<i>P</i> = 0.01).</p><h3>Conclusion</h3><p>The findings highlighted the importance of felids as potential intermediate hosts of neosporosis despite the fact that the source of the parasite for these animals was unknown. Further studies should be performed to investigate the role of this top predator (felids) in maintaining both domestic and sylvatic cycles of <i>Neospora caninum.</i></p></div>\",\"PeriodicalId\":6932,\"journal\":{\"name\":\"Acta Parasitologica\",\"volume\":\"68 1\",\"pages\":\"266 - 276\"},\"PeriodicalIF\":1.2000,\"publicationDate\":\"2023-01-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta Parasitologica\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s11686-023-00661-6\",\"RegionNum\":3,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"PARASITOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Parasitologica","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s11686-023-00661-6","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PARASITOLOGY","Score":null,"Total":0}
Systematic Review and Meta-analysis of Role of Felids as Intermediate Hosts in the Life Cycle of Neospora caninum Based on Serological Data
Purpose
Neosporosis is an important widespread parasitic infection caused by N. caninum. It infects a wide range of warm-blooded animals as intermediate hosts and dogs as the definitive host. Nevertheless, there are a number of questions regarding the life cycle and epidemiological aspects of N. caninum. Also, the role of felids (domestic and non-domestic) in the life cycle of N. caninum has been little described. Therefore, this study was conducted to evaluate the global prevalence of N. caninum in domestic and wild felids.
Methods
PubMed, Scopus, Google Scholar, Web of Science, and ScienceDirect databases were searched for articles published on the prevalence of N. caninum in felids until Aprill 2, 2022 and the reference lists of retrieved articles were screened. A random-effects meta-analysis model was used to estimate the pooled prevalence and 95% confidence interval. Heterogeneity among studies was evaluated using Cochran’s Q and the I2 statistic.
Results
After exclusion of irrelevant articles and duplication removal, 30 studies were eligible for quantitative analysis including 20 studies on domestic cats and 10 studies on wild felids. The overall prevalence of neosporosis infection in cats was 15% (95% CI 10–21%) that was significantly higher in wild felids (26%, 95% CI 13–38%) than in domestic cats (11%, 95% CI 6–16%) (P = 0.03). There was no significant difference in pooled prevalence between male and female domestic cats (P = 0.75). Regarding continent, the lowest prevalence of neosporosis infection was in Asia (9%, 95% CI 1–20%) and the highest was in North America (43.6%, 95% CI 33.9–53.2%) and Africa (18%, 95% CI 9–46%). Higher prevalence was obtained when using the NAT with 22% (95% CI 7–37%), compared to the IFAT (17%, 95% CI 9–24%) and ELISA (6%, 95% CI 2–9%) (P = 0.01).
Conclusion
The findings highlighted the importance of felids as potential intermediate hosts of neosporosis despite the fact that the source of the parasite for these animals was unknown. Further studies should be performed to investigate the role of this top predator (felids) in maintaining both domestic and sylvatic cycles of Neospora caninum.
期刊介绍：
Acta Parasitologica is an international journal covering the latest advances in the subject.
Acta Parasitologica publishes original papers on all aspects of parasitology and host-parasite relationships, including the latest discoveries in biochemical and molecular biology of parasites, their physiology, morphology, taxonomy and ecology, as well as original research papers on immunology, pathology, and epidemiology of parasitic diseases in the context of medical, veterinary and biological sciences. The journal also publishes short research notes, invited review articles, book reviews.
The journal was founded in 1953 as "Acta Parasitologica Polonica" by the Polish Parasitological Society and since 1954 has been published by W. Stefanski Institute of Parasitology of the Polish Academy of Sciences in Warsaw. Since 1992 in has appeared as Acta Parasitologica in four issues per year.
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