线性糊精姜黄素保护递送体系的制备与表征

Compounds Pub Date : 2022-11-16 DOI:10.3390/compounds2040029
Huifang Xie, Litao Ma, Yanan Li, Junqing Fu, Zhongxian Li, Xuejun Yu, Qunyu Gao
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引用次数: 2

摘要

以马铃薯蜡质淀粉为原料,经巴氏杀菌和普鲁兰酶解支法制备了F-40片段(DP = 31.44)的线性糊精(LDs),并用不同浓度的乙醇溶液分离提取。将其包封在疏水配体姜黄素中,开发出一种能提高其在食品中的风味和药物中的功能的控释体系。研究了包合物的理化性质和包封机理。结果表明,配合物对姜黄素的负载能力、包封率和产率与LD的分子量有关。LD- cur配合物的产率、包封率和姜黄素的负载率分别为19.86%、25.81%和29.52 μg/mg,而F-40-Cur配合物的产率、包封率和负载姜黄素的产率分别为75.98%、29.97%和37.52 μg/mg。LD与姜黄素之间存在氢键和疏水相互作用,其中F-40与姜黄素之间以氢键相互作用为主。姜黄素以无定形形式存在于络合物中。与LD络合后姜黄素光热稳定性提高,与F-40络合后进一步显著增强。姜黄素在肠道中的释放更加有效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Preparation and Characterizations of Curcumin Protection and Delivery System Using Linear Dextrin
In this work, linear dextrins (LDs) with the fragment F-40 (DP = 31.44) were fabricated from waxy potato starch through pasteurization and enzymatic debranching by pullulanase and then separated and extracted by ethanol solutions with different concentrations. The LDs were used to encapsulate hydrophobic ligand curcumin to develop a controlled release system that would increase its flavor in food and functions in medicines. The physicochemical properties and the encapsulation mechanism of the inclusion complexes were investigated. It was found that the loading capability for curcumin, the encapsulation rate, and the yield of the complexes depended on the molecular weight of LD. The yield of the LD-Cur complex, its encapsulation rate, and loading of curcumin were 19.86%, 25.81%, and 29.52 μg/mg, respectively, while the yield of the F-40-Cur complex, its inclusion rate, and loading curcumin reached up to 75.98%, 29.97%, and 37.52 μg/mg, respectively. There were both hydrogen bonding and hydrophobic interactions between LD and curcumin, while hydrogen bonding interactions were predominant between F-40 and curcumin. Curcumin was presented in the complex in an amorphous form. The photothermal stability of curcumin increased after being complexed with LD and further enhanced significantly with F-40. The release of curcumin in the intestine was achieved much more effectively.
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CiteScore
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