在小鼠后肢缺血模型中，口服干酪乳杆菌ATCC393通过增强中性粒细胞活性促进血管生成。

IF 3.1 4区医学 Q2 Agricultural and Biological Sciences

Bioscience of Microbiota, Food and Health Pub Date : 2023-01-01 DOI:10.12938/bmfh.2022-038

Suguru Saito, Musin Kelel

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引用次数: 0

摘要

血管生成是一个高度调控的生物事件，需要中性粒细胞(先天免疫细胞)的参与来启动系统反应。一些乳酸菌(LAB)菌株可以作为益生菌，在我们的免疫系统中提供功能修改。本研究表明，口服干酪乳杆菌ATCC393可促进炎症血管生成，同时增强中性粒细胞活性。热杀干酪乳杆菌(HK-LC)可改善小鼠后肢缺血(HLI)模型的血管生成。在HLI条件下，HK-LC可增强中性粒细胞的招募和活性。我们的研究结果提供了新的证据，证明LAB摄取在预防心血管疾病或从心血管疾病中恢复的免疫学贡献。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Oral administration of Lacticaseibacillus casei ATCC393 promotes angiogenesis by enhancing neutrophil activity in a murine hind-limb ischemia model.

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Oral administration of Lacticaseibacillus casei ATCC393 promotes angiogenesis by enhancing neutrophil activity in a murine hind-limb ischemia model.

Angiogenesis is a highly regulated biological event and requires the participation of neutrophils, which are innate immune cells, to initiate the systematic responses. Some strains of lactic acid bacteria (LAB) can be used for probiotics that provide functional modifications in our immune systems. Here, we show that oral administration of Lacticaseibacillus casei ATCC393 promoted inflammatory angiogenesis accompanied by enhanced neutrophil activity. Heat-killed L. casei (HK-LC) administration improved angiogenesis in a murine hind-limb ischemia (HLI) model. The recruitment and activity of neutrophils were enhanced by HK-LC administration under the HLI conditions. Our results provide novel evidence of an immunological contribution of LAB uptake in the prevention of or recovery from cardiovascular diseases.

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来源期刊

Bioscience of Microbiota, Food and Health Immunology and Microbiology-Applied Microbiology and Biotechnology

CiteScore

5.50

自引率

3.20%

发文量

期刊介绍： Bioscience of Microbiota, Food and Health (BMFH) is a peer-reviewed scientific journal with a specific area of focus: intestinal microbiota of human and animals, lactic acid bacteria (LAB) and food immunology and food function. BMFH contains Full papers, Notes, Reviews and Letters to the editor in all areas dealing with intestinal microbiota, LAB and food immunology and food function. BMFH takes a multidisciplinary approach and focuses on a broad spectrum of issues.