α 1d肾上腺素受体在血管紧张素ii诱导的高血压中血管壁肥厚的作用

I. A. Gallardo-Ortíz, S. N. Rodríguez-Hernández, J. J. López-Guerrero, L. Del Valle-Mondragón, P. López-Sánchez, R. M. Touyz, R. Villalobos-Molina
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引用次数: 17

摘要

探讨持续输注血管紧张素II (Ang II)在体内对动脉血压、血管肥大及α1-肾上腺素受体(α1-ARs)表达的影响。在雄性Wistar大鼠(3个月大)皮下植入充满Ang II (200 ng kg−1 min−1)的Alzet®微型泵。各组大鼠也用AT1R拮抗剂氯沙坦或选择性α1D-AR拮抗剂BMY 7378治疗。用尾袖测量血压;治疗2或4周后,分离血管进行功能和结构分析。血管紧张素II增加收缩压。苯肾上腺素诱导的大鼠主动脉收缩比对照组更大(高出40%),KCl 80mm也有类似的效果。尾动脉的反应在不同组间无显著差异。血管紧张素II降低α1D-ARs,但不影响其他α1-ARs,导致主动脉中膜厚度增加(肥厚),尾动脉未发生结构改变。氯沙坦预防和逆转高血压和肥厚,而BMY 7378预防和逆转主动脉肥厚反应,但未预防或逆转高血压。结果表明,Ang ii诱导的主动脉肥厚反应涉及Ang II-AT1Rs和α1D-ARs。血管紧张素ii诱导的α - 1d - ar介导的血管重构与高血压无关。研究结果确定了α 1d - ar介导的过程,其中Ang II独立于血压升高影响主动脉肥厚。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Role of α1D-adrenoceptors in vascular wall hypertrophy during angiotensin II-induced hypertension

  1. The in vivo effect of continuous angiotensin II (Ang II) infusion on arterial blood pressure, vascular hypertrophy and α1-adrenoceptors (α1-ARs) expression was explored.
  2. Alzet® minipumps filled with Ang II (200 ng kg−1 min−1) were subcutaneously implanted in male Wistar rats (3 months-old). Groups of rats were also treated with losartan, an AT1R antagonist, or with BMY 7378, a selective α1D-AR antagonist. Blood pressure was measured by tail-cuff; after 2 or 4 weeks of treatment, vessels were isolated for functional and structural analyses.
  3. Angiotensin II increased systolic blood pressure. Phenylephrine-induced contraction in aorta was greater (40% higher) in Ang II-treated rats than in the controls, and similar effect occurred with KCl 80 mm. Responses in tail arteries were not significantly different among the different groups.
  4. Angiotensin II decreased α1D-ARs without modifying the other α1-ARs and induced an increase in media thickness (hypertrophy) in aorta, while no structural change occurred in tail artery. Losartan prevented and reversed hypertension and hypertrophy, while BMY 7378 prevented and reversed the aorta's hypertrophic response, without preventing or reversing hypertension. Findings indicate that Ang II-induced aortic hypertrophic response involves Ang II-AT1Rs and α1D-ARs. Angiotensin II-induced α1D-AR-mediated vascular remodeling occurs independently of hypertension.
  5. Findings identify a α1D-AR-mediated process whereby Ang II influences aortic hypertrophy independently of blood pressure elevation.
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