Silvia Baroncelli , Clementina Maria Galluzzo , Stefano Orlando , Robert Mphwere , Thom Kavalo , Richard Luhanga , Roberta Amici , Marco Floridia , Mauro Andreotti , Paola Scarcella , Maria Cristina Marazzi , Marina Giuliano
{"title":"2020年2月至2021年5月期间马拉维婴儿接触SARS-CoV-2的动态","authors":"Silvia Baroncelli , Clementina Maria Galluzzo , Stefano Orlando , Robert Mphwere , Thom Kavalo , Richard Luhanga , Roberta Amici , Marco Floridia , Mauro Andreotti , Paola Scarcella , Maria Cristina Marazzi , Marina Giuliano","doi":"10.1016/j.jcvp.2022.100110","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Very limited information is available on SARS-CoV-2 seroprevalence in infants in sub-Saharan countries.</p></div><div><h3>Objective</h3><p>In this study, we aimed to determine the rate and the temporal evolution of SARS CoV-2 seropositivity in breastfed Malawian infants.</p></div><div><h3>Study design</h3><p>Blood samples (<em>n</em> = 250) from 158 infants, born to HIV-negative women and women living with HIV, collected from February 2020 to May 2021, were first tested using an Anti-IgG/A/M SARS CoV 2 ELISA assay against trimeric spike protein, and then, if positive, confirmed using a second ELISA assay detecting IgG against Receptor Binding Domain.</p></div><div><h3>Results</h3><p>The confirmed prevalence of anti-SARS CoV-2 antibodies was 31.0% (95% CI: 23.7%-38.3%) with no significant difference between HIV-exposed and HIV-unexposed infants (29.3% and 37.1% respectively, <em>P</em> = 0.410). The presence of anti-SARS-CoV-2 IgG was not associated with maternal socioeconomic or demographic indices.</p></div><div><h3>Conclusions</h3><p>Our data underline the wide spread of the SARS-CoV-2 infection in the pediatric population in sub-Saharan Africa. Design of more specific serological tests for African samples and improvements in serosurveillance programs are needed for more rigorous monitoring of the dynamics of SARS-CoV-2 infection in Africa.</p></div>","PeriodicalId":73673,"journal":{"name":"Journal of clinical virology plus","volume":"2 4","pages":"Article 100110"},"PeriodicalIF":1.6000,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477783/pdf/","citationCount":"1","resultStr":"{\"title\":\"Dynamics of SARS-CoV-2 exposure in Malawian infants between February 2020 and May 2021\",\"authors\":\"Silvia Baroncelli , Clementina Maria Galluzzo , Stefano Orlando , Robert Mphwere , Thom Kavalo , Richard Luhanga , Roberta Amici , Marco Floridia , Mauro Andreotti , Paola Scarcella , Maria Cristina Marazzi , Marina Giuliano\",\"doi\":\"10.1016/j.jcvp.2022.100110\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Very limited information is available on SARS-CoV-2 seroprevalence in infants in sub-Saharan countries.</p></div><div><h3>Objective</h3><p>In this study, we aimed to determine the rate and the temporal evolution of SARS CoV-2 seropositivity in breastfed Malawian infants.</p></div><div><h3>Study design</h3><p>Blood samples (<em>n</em> = 250) from 158 infants, born to HIV-negative women and women living with HIV, collected from February 2020 to May 2021, were first tested using an Anti-IgG/A/M SARS CoV 2 ELISA assay against trimeric spike protein, and then, if positive, confirmed using a second ELISA assay detecting IgG against Receptor Binding Domain.</p></div><div><h3>Results</h3><p>The confirmed prevalence of anti-SARS CoV-2 antibodies was 31.0% (95% CI: 23.7%-38.3%) with no significant difference between HIV-exposed and HIV-unexposed infants (29.3% and 37.1% respectively, <em>P</em> = 0.410). The presence of anti-SARS-CoV-2 IgG was not associated with maternal socioeconomic or demographic indices.</p></div><div><h3>Conclusions</h3><p>Our data underline the wide spread of the SARS-CoV-2 infection in the pediatric population in sub-Saharan Africa. Design of more specific serological tests for African samples and improvements in serosurveillance programs are needed for more rigorous monitoring of the dynamics of SARS-CoV-2 infection in Africa.</p></div>\",\"PeriodicalId\":73673,\"journal\":{\"name\":\"Journal of clinical virology plus\",\"volume\":\"2 4\",\"pages\":\"Article 100110\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2022-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477783/pdf/\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of clinical virology plus\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2667038022000497\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of clinical virology plus","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2667038022000497","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
Dynamics of SARS-CoV-2 exposure in Malawian infants between February 2020 and May 2021
Background
Very limited information is available on SARS-CoV-2 seroprevalence in infants in sub-Saharan countries.
Objective
In this study, we aimed to determine the rate and the temporal evolution of SARS CoV-2 seropositivity in breastfed Malawian infants.
Study design
Blood samples (n = 250) from 158 infants, born to HIV-negative women and women living with HIV, collected from February 2020 to May 2021, were first tested using an Anti-IgG/A/M SARS CoV 2 ELISA assay against trimeric spike protein, and then, if positive, confirmed using a second ELISA assay detecting IgG against Receptor Binding Domain.
Results
The confirmed prevalence of anti-SARS CoV-2 antibodies was 31.0% (95% CI: 23.7%-38.3%) with no significant difference between HIV-exposed and HIV-unexposed infants (29.3% and 37.1% respectively, P = 0.410). The presence of anti-SARS-CoV-2 IgG was not associated with maternal socioeconomic or demographic indices.
Conclusions
Our data underline the wide spread of the SARS-CoV-2 infection in the pediatric population in sub-Saharan Africa. Design of more specific serological tests for African samples and improvements in serosurveillance programs are needed for more rigorous monitoring of the dynamics of SARS-CoV-2 infection in Africa.
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