吸入治疗的新型改良释放给药系统的发展前景。

IF 5 2区 医学 Q1 PHARMACOLOGY & PHARMACY
Expert Opinion on Drug Delivery Pub Date : 2023-03-01 Epub Date: 2023-02-16 DOI:10.1080/17425247.2023.2175814
Tanvirul Hye, Sakib M Moinuddin, Tanoy Sarkar, Trieu Nguyen, Dipongkor Saha, Fakhrul Ahsan
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引用次数: 1

摘要

导读:经肺给药的药物主要用于治疗各种呼吸系统疾病,包括哮喘、慢性阻塞性肺疾病、呼吸道感染和肺癌,以及肺动脉高压等肺血管疾病。为了治疗呼吸系统疾病,有针对性的、改良的或控制释放的吸入制剂是改善患者依从性和优越治疗结果的理想选择。涵盖的领域:本文综述了影响可吸入修饰释放制剂方法的重要因素,重点介绍了各种制剂策略,包括溶出速率控制系统、药物复合物、位点特异性递送、药物-聚合物偶联物、药物-聚合物基质系统、脂质基质颗粒、纳米系统和可绕过粘膜纤毛系统和肺泡巨噬细胞清除的制剂。专家意见:吸入改性释放制剂可以通过延长药物在肺部的停留时间来潜在地减少给药频率。然而,从商业化的角度来看,可吸入的修饰或控释药物递送系统仍未被探索和开发。本文综述了目前吸入控释制剂的最新技术,阐述了开发新技术的途径,以在吸入给药后制定量身定制的释放概况,并解释了与修饰释放可吸入制剂转化可行性相关的挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
An evolving perspective on novel modified release drug delivery systems for inhalational therapy.

Introduction: Drugs delivered via the lungs are predominantly used to treat various respiratory disorders, including asthma, chronic obstructive pulmonary diseases, respiratory tract infections and lung cancers, and pulmonary vascular diseases such as pulmonary hypertension. To treat respiratory diseases, targeted, modified or controlled release inhalation formulations are desirable for improved patient compliance and superior therapeutic outcome.

Areas covered: This review summarizes the important factors that have an impact on the inhalable modified release formulation approaches with a focus toward various formulation strategies, including dissolution rate-controlled systems, drug complexes, site-specific delivery, drug-polymer conjugates, and drug-polymer matrix systems, lipid matrix particles, nanosystems, and formulations that can bypass clearance via mucociliary system and alveolar macrophages.

Expert opinion: Inhaled modified release formulations can potentially reduce dosing frequency by extending drug's residence time in the lungs. However, inhalable modified or controlled release drug delivery systems remain unexplored and underdeveloped from the commercialization perspective. This review paper addresses the current state-of-the-art of inhaled controlled release formulations, elaborates on the avenues for developing newer technologies for formulating various drugs with tailored release profiles after inhalational delivery and explains the challenges associated with translational feasibility of modified release inhalable formulations.

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来源期刊
CiteScore
11.10
自引率
3.00%
发文量
104
审稿时长
3 months
期刊介绍: Expert Opinion on Drug Delivery (ISSN 1742-5247 [print], 1744-7593 [electronic]) is a MEDLINE-indexed, peer-reviewed, international journal publishing review articles covering all aspects of drug delivery research, from initial concept to potential therapeutic application and final relevance in clinical use. Each article is structured to incorporate the author’s own expert opinion on the scope for future development.
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