墨西哥妇女的腹部肥胖、过度肥胖和 Taq1B CETP 变异与血清脂质水平呈正相关。

IF 2 4区 医学 Q3 GENETICS & HEREDITY
Lifestyle Genomics Pub Date : 2023-01-01 Epub Date: 2023-01-18 DOI:10.1159/000529053
Mariana Perez-Robles, Wendy Campos-Perez, Joel Torres-Vanegas, Sarai Citlalic Rodriguez-Reyes, Juan José Rivera-Valdés, Erika Martínez-Lopez
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引用次数: 0

摘要

引言肥胖症是一种普遍存在的多因素疾病,其主要并发症是血脂异常。血清脂质水平也取决于遗传因素,包括 CETP 基因的 Taq1B 变体。因此,本研究旨在确定 Taq1B CETP 变体对血清脂质水平的影响与人体测量变量的关系。体重和体脂用生物阻抗测量,腰围用卷尺测量。血清脂质水平通过干化学法测定。通过等位基因辨别分析了 Taq1B CETP 变体:结果:腹部肥胖和 B1B2/B2B2 基因型女性的总胆固醇水平(195.17 [185.95-204.39] vs. 183 mg/dL [169.83-196.16],p = 0.007)和低密度脂蛋白水平(118.84 [110.65-127.03] vs. 113.84 mg/dL [102.37-125.31],p = 0.037)明显高于 B1B1 基因型携带者。同样,过度肥胖和 B1B2/B2B2 基因型受试者的总胆固醇水平(195.05 [186.04-204.06] vs. 182.40 mg/dL [169.03-195.76],p = 0.003)也明显高于 B1B1 基因型受试者:结论:腹部肥胖或过度肥胖的女性,如果也是 B1B2/B2B2 基因型携带者,其血清脂质水平要高于 B1B1 基因型女性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Abdominal Obesity, Excessive Adiposity, and the Taq1B CETP Variant Are Positively Associated with Serum Lipid Levels in Mexican Women.

Introduction: Obesity is a prevalent multifactorial disease whose main complication is dyslipidemia. Serum lipid levels also depend on genetic factors including the Taq1B variant of the CETP gene, which is suggested to be influenced by environmental factors and adiposity. Therefore, this study aimed to determine the effect of the Taq1B CETP variant on serum lipid levels associated with anthropometrical variables.

Methods: 165 women from western Mexico were enrolled in this cross-sectional study. Weight and body fat were measured by bioimpedance and waist circumference with a measuring tape. Serum lipid levels were determined by dry chemistry. The Taq1B CETP variant was analyzed by allelic discrimination.

Results: Women with abdominal obesity and the B1B2/B2B2 genotype had significantly higher total cholesterol levels (195.17 [185.95-204.39] vs. 183 mg/dL [169.83-196.16], p = 0.007) and low density lipoprotein (118.84 [110.65-127.03] vs. 113.84 mg/dL [102.37-125.31], p = 0.037) than carriers of the B1B1 genotype. Likewise, subjects with excessive adiposity and the B1B2/B2B2 genotype showed significantly higher total cholesterol levels (195.05 [186.04-204.06] vs. 182.40 mg/dL [169.03-195.76], p = 0.003) than those with the B1B1 genotype.

Conclusion: Women with abdominal obesity or excessive adiposity, who are also carriers of the B1B2/B2B2 genotype, have higher serum lipid levels than women with the B1B1 genotype.

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来源期刊
Lifestyle Genomics
Lifestyle Genomics Agricultural and Biological Sciences-Food Science
CiteScore
4.00
自引率
7.70%
发文量
11
审稿时长
28 weeks
期刊介绍: Lifestyle Genomics aims to provide a forum for highlighting new advances in the broad area of lifestyle-gene interactions and their influence on health and disease. The journal welcomes novel contributions that investigate how genetics may influence a person’s response to lifestyle factors, such as diet and nutrition, natural health products, physical activity, and sleep, amongst others. Additionally, contributions examining how lifestyle factors influence the expression/abundance of genes, proteins and metabolites in cell and animal models as well as in humans are also of interest. The journal will publish high-quality original research papers, brief research communications, reviews outlining timely advances in the field, and brief research methods pertaining to lifestyle genomics. It will also include a unique section under the heading “Market Place” presenting articles of companies active in the area of lifestyle genomics. Research articles will undergo rigorous scientific as well as statistical/bioinformatic review to ensure excellence.
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