TLR-4基因在人体天然免疫系统功能及慢性丙型肝炎免疫发病机制中的作用(文献综述)

IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL
T. Koval, L. Syzova, N. O. Pryimenko, A. Sydorenko, M.V. Kulіsh, V. Ilchenko, N. Lymarenko
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引用次数: 0

摘要

迄今为止,尽管对慢性丙型肝炎(CHC)免疫发病机制的研究取得了重大进展,但在诊断、预测和治疗过程中仍存在许多悬而未决的问题。在研究这种感染的背景下,先天免疫系统受体(TLRs)的toll样基因家族引起了相当大的兴趣。本文就TLR-4基因在人体天然免疫系统功能中的作用,以及该基因的Asp299Gly多态性在CHC免疫发病中的作用等方面的专业科学资料进行分析和总结。该研究的相关性是由于先天免疫系统在大型生物体免受病原体侵害的主要保护中至关重要,其识别在很大程度上取决于TLRs受体基因家族,遗传分析是个性化医疗的现代和有前途的方向。确定遗传标记的重要性在于,无论年龄和外部和内部环境的其他因素如何,它们都携带有关易患各种疾病的信息,这些信息可用于形成遗传通行证。关于TLR4基因Asp299Gly多态性对CHC免疫发病机制影响的数据相互矛盾,有待进一步研究。对这一问题的深入研究将基于对免疫反应特征的综合评估来改善该病的治疗和诊断策略,这些免疫反应是由人类基因组中所指示的多态性的携带引起的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The role of TLR-4 gene in the functioning of the natural human immune system and the immunopathogenesis of chronic hepatitis C (literature review)
To date, despite significant advances in the study of the immunopathogenesis of chronic hepatitis C (CHC), many open questions remain in the diagnosis, prediction and course of treatment. In the context of the study of this infection, the Toll-like gene family of innate immune system receptors (TLRs) is of considerable interest. The article analyzes and summarizes the data of professional scientific sources on the role of the TLR-4 gene in the functioning of the natural human immune system, as well as Asp299Gly polymorphism of this gene in the immunopathogenesis of CHC. The relevance of the study is due to the fact that the innate immune system is crucial in the primary protection of the macroorganism from pathogens, the recognition of which largely depends on the TLRs receptor gene family, and genetic analysis is a modern and promising direction in personalized medicine. The importance of determining genetic markers lies in the fact that regardless of age and other factors of the external and internal environment, they carry information about the predisposition to various diseases, which can be used in the formation of a genetic passport. The data concerning the influence of the Asp299Gly polymorphism of the TLR4 gene on the immunopathogenesis of CHC are contradictory and require further investigation. An in-depth study of this issue will improve the therapeutic and diagnostic tactics of this disease based on a comprehensive assessment of the features of the immune response, which are caused by the carriage of the indicated polymorphism in the human genome.
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来源期刊
Medical Perspectives-Medicni Perspektivi
Medical Perspectives-Medicni Perspektivi MEDICINE, GENERAL & INTERNAL-
CiteScore
0.40
自引率
0.00%
发文量
85
审稿时长
9 weeks
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