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引用次数: 2
摘要
几十年来对植物的遗传、分子和生化研究为光感蛋白提供了基础知识，并将其应用于合成生物学。光遗传学工具利用植物光感受器的光可切换活性来控制细胞内信号通路。最近在模式植物拟南芥中发现了UV-B光感受器UV RESISTANCE LOCUS 8，为光控制方法开辟了新的途径。在这篇综述中，我们讨论了UV-B光及其信号成分在光遗传学控制方面的最新进展，以及在设计和应用基于UV-B的光遗传学工具时的合理考虑。
Optogenetic tools controlled by ultraviolet-B light
Decades of genetic, molecular and biochemical studies in plants have provided foundational knowledge about light sensory proteins and led to their application in synthetic biology. Optogenetic tools take advantage of the light switchable activity of plant photoreceptors to control intracellular signaling pathways. The recent discovery of the UV-B photoreceptor UV RESISTANCE LOCUS 8 in the model plant Arabidopsis thaliana opens up new avenues for light-controllable methodologies. In this review, we discuss current developments in optogenetic control by UV-B light and its signaling components, as well as rational considerations in the design and applications of UV-B-based optogenetic tools.
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