Jorge Rico-Fontalvo, José Correa-Guerrero, María Cristina Martínez-Ávila, Rodrigo Daza-Arnedo, Tomás Rodriguez-Yanez, Amilkar Almanza-Hurtado, José Cabrales, Carmen Julia Mendoza-Paternina, Alvaro Frías-Salazar, Julio Morales-Fernández
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Critically Ill Patients with Renal Hyperfiltration: Optimizing Antibiotic Dose.
Renal hyperfiltration (RHF) is a prevalent phenomenon in critically ill patients characterized by augmented renal clearance (ARC) and increased of elimination of renally eliminated medications. Multiple risk factors had been described and potential mechanisms may contribute to the occurrence of this condition. RHF and ARC are associated with the risk of suboptimal exposure to antibiotics increasing the risk of treatment failure and unfavorable patient outcomes. The current review discusses the available evidence related to the RHF phenomenon, including definition, epidemiology, risk factors, pathophysiology, pharmacokinetic variability, and considerations for optimizing the dosage of antibiotics in critically ill patients.
期刊介绍：
International Journal of Nephrology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies focusing on the prevention, diagnosis, and management of kidney diseases and associated disorders. The journal welcomes submissions related to cell biology, developmental biology, genetics, immunology, pathology, pathophysiology of renal disease and progression, clinical nephrology, dialysis, and transplantation.
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