下丘脑内催产素对PVN CRH神经元在急性应激反应中的作用

Current Opinion in Endocrine and Metabolic Research Pub Date : 2022-10-01 DOI:10.1016/j.coemr.2022.100382

Dipa Pati , Eric G. Krause , Charles J. Frazier

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引用次数: 1

摘要

大部分中央可用的催产素(OT)是在位于下丘脑室旁核的大细胞神经元中合成的。这一区域也是促肾上腺皮质激素释放激素(CRH)合成神经元的所在地，这些神经元负责调节下丘脑-垂体-肾上腺(HPA)轴的激活。大量数据表明，这些系统之间复杂的相互作用不可避免地将中枢OT信号与神经内分泌对应激的反应联系起来。这篇综述的重点是一组小而多样的细胞和突触机制，这些机制被认为是在急性应激反应中下丘脑内OT/CRH相互作用的基础。

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Intrahypothalamic effects of oxytocin on PVN CRH neurons in response to acute stress

Much of the centrally available oxytocin (OT) is synthesized in magnocellular neurons located in the paraventricular nucleus of the hypothalamus. This same area is home to parvocellular corticotropin-releasing hormone (CRH) synthesizing neurons that regulate activation of the hypothalamic-pituitary-adrenal (HPA) axis. A large body of data indicates that complex interactions between these systems inextricably link central OT signaling with the neuroendocrine response to stress. This review focuses on a small but diverse set of cellular and synaptic mechanisms that have been proposed to underlie intrahypothalamic OT/CRH interactions during the response to acute stress.

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来源期刊

Current Opinion in Endocrine and Metabolic Research Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

4.10

自引率

0.00%

发文量