提高银屑病患者甲板营养不良病变治疗效果的方法

T. Lytynska, L. Naumova
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引用次数: 0

摘要

目的:通过外用药物Onychocid®Emtrix的复合治疗,提高银屑病患者指甲退行性改变的治疗效果,旨在恢复甲板的完整性。材料和方法。本文对38例银屑病伴不同形式甲关节营养不良(OD)的患者进行了检查和治疗。根据治疗结果评价治疗效果,将患者分为两组:主要组和对照组。两组患者均接受基础治疗。另外,主组患者给予Onychocid®Emtrix联合用药,每日1次涂抹于甲板及受损指甲尖下,疗程3 - 6个月。结果和讨论。牛皮癣患者被诊断为不同程度的甲板营养不良变化。14例(36.8%)患者仅检出手指外径;脚趾- 5例(13.2%);手指和脚趾同时发生- 19例(50.0%)患者。由于复杂的治疗,在主组患者中,早期(已经在使用药物Onychocid®Emtrix的2 - 4周)畸形指甲的外观得到改善。经过疗程治疗后,这些患者均表现出良好的临床效果。钉板厚度减少,密度、颜色和结构不规整。同时,34例(89.5%)患者出现“显著改善”和“改善”,3例(7.9%)患者出现“轻微改善”,1例(2.6%)患者出现“无改善”。结论。银屑病患者的营养不良指甲病变的治疗应复杂和重点,包括恢复指甲板的完整性。在银屑病OD患者的复杂治疗中加入联合药物Onychocid®Emtrix可提高治疗效果,特别是有助于恢复甲板的结构、形状、完整性、厚度和颜色。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Ways to increase the effectiveness of treatment of psoriasis patients with dystrophic lesions of the nail plates
Objective — to increase the effectiveness of treatment of psoriasis patients with degenerative changes in the nails, by including in the complex therapy of the topical drug Onychocid® Emtrix, aimed at restoring the integrity of the nail plates. Materials and methods. 38 patients with psoriasis and various forms of onychodystrophy (OD) were examined and treated. The effectiveness of therapy was evaluated based on the results of treatment of patients who were divided into two clinical groups — the main and the comparison ones. Patients in both groups received basic therapy. In addition, patients of the main group were prescribed a combined drug Onychocid® Emtrix, which was applied on the nail plates and under the tips of damaged nails once a day for 3 – 6 months. Results and discussion. Patients with psoriasis are diagnosed with dystrophic changes of nail plates of varying severity. OD of the fingers only was detected in 14 (36.8 %) patients; toes — in 5 (13.2 %); fingers and toes at the same time — in 19 (50.0 %) patients. As a result of complex treatment, in patients of the main group there was an early (already on the 2—4th week of use of the drug Onychocid® Emtrix) improvement of the appearance of deformed nails. After the course of treatment, these patients showed a positive clinical effect, i. e. decrease in thickness, normalization of density, color and structure of nail plates. At the same time, «significant improvement» and «improvement» were noted in 34 (89.5 %), «slight improvement» — in 3 (7.9 %), «no improvement» — in 1 (2.6 %) patients. Conclusions. Treatment of psoriasis patients with dystrophic nail lesions should be complex and focused, including the restoration of the integrity of the nail plates. The inclusion in the complex therapy of patients with psoriatic OD of the combined drug Onychocid® Emtrix increases the effectiveness of treatment, in particular, helps to restore the structure, shape, integrity, thickness and color of the nail plates.
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