{"title":"细颗粒物对血睾屏障的影响及其潜在机制。","authors":"Shaokai Zheng, Lianlian Jiang, Lianglin Qiu","doi":"10.1515/reveh-2022-0204","DOIUrl":null,"url":null,"abstract":"<p><p>With the rapid expansion of industrial scale, an increasing number of fine particulate matter (PM<sub>2.5</sub>) has bringing health concerns. Although exposure to PM<sub>2.5</sub> has been clearly associated with male reproductive toxicity, the exact mechanisms are still unclear. Recent studies demonstrated that exposure to PM<sub>2.5</sub> can disturb spermatogenesis through destroying the blood-testis barrier (BTB), consisting of different junction types, containing tight junctions (TJs), gap junctions (GJs), ectoplasmic specialization (ES) and desmosomes. The BTB is one of the tightest blood-tissue barriers among mammals, which isolating germ cells from hazardous substances and immune cell infiltration during spermatogenesis. Therefore, once the BTB is destroyed, hazardous substances and immune cells will enter seminiferous tubule and cause adversely reproductive effects. In addition, PM<sub>2.5</sub> also has shown to cause cells and tissues injury via inducing autophagy, inflammation, sex hormones disorder, and oxidative stress. However, the exact mechanisms of the disruption of the BTB, induced by PM<sub>2.5</sub>, are still unclear. It is suggested that more research is required to identify the potential mechanisms. In this review, we aim to understand the adverse effects on the BTB after exposure to PM<sub>2.5</sub> and explore its potential mechanisms, which provides novel insight into accounting for PM<sub>2.5</sub>-induced BTB injury.</p>","PeriodicalId":21165,"journal":{"name":"Reviews on Environmental Health","volume":null,"pages":null},"PeriodicalIF":3.0000,"publicationDate":"2022-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The effects of fine particulate matter on the blood-testis barrier and its potential mechanisms.\",\"authors\":\"Shaokai Zheng, Lianlian Jiang, Lianglin Qiu\",\"doi\":\"10.1515/reveh-2022-0204\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>With the rapid expansion of industrial scale, an increasing number of fine particulate matter (PM<sub>2.5</sub>) has bringing health concerns. Although exposure to PM<sub>2.5</sub> has been clearly associated with male reproductive toxicity, the exact mechanisms are still unclear. Recent studies demonstrated that exposure to PM<sub>2.5</sub> can disturb spermatogenesis through destroying the blood-testis barrier (BTB), consisting of different junction types, containing tight junctions (TJs), gap junctions (GJs), ectoplasmic specialization (ES) and desmosomes. The BTB is one of the tightest blood-tissue barriers among mammals, which isolating germ cells from hazardous substances and immune cell infiltration during spermatogenesis. Therefore, once the BTB is destroyed, hazardous substances and immune cells will enter seminiferous tubule and cause adversely reproductive effects. In addition, PM<sub>2.5</sub> also has shown to cause cells and tissues injury via inducing autophagy, inflammation, sex hormones disorder, and oxidative stress. However, the exact mechanisms of the disruption of the BTB, induced by PM<sub>2.5</sub>, are still unclear. It is suggested that more research is required to identify the potential mechanisms. In this review, we aim to understand the adverse effects on the BTB after exposure to PM<sub>2.5</sub> and explore its potential mechanisms, which provides novel insight into accounting for PM<sub>2.5</sub>-induced BTB injury.</p>\",\"PeriodicalId\":21165,\"journal\":{\"name\":\"Reviews on Environmental Health\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2022-11-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Reviews on Environmental Health\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1515/reveh-2022-0204\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/6/25 0:00:00\",\"PubModel\":\"Print\",\"JCR\":\"Q2\",\"JCRName\":\"ENVIRONMENTAL SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Reviews on Environmental Health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1515/reveh-2022-0204","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/6/25 0:00:00","PubModel":"Print","JCR":"Q2","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
The effects of fine particulate matter on the blood-testis barrier and its potential mechanisms.
With the rapid expansion of industrial scale, an increasing number of fine particulate matter (PM2.5) has bringing health concerns. Although exposure to PM2.5 has been clearly associated with male reproductive toxicity, the exact mechanisms are still unclear. Recent studies demonstrated that exposure to PM2.5 can disturb spermatogenesis through destroying the blood-testis barrier (BTB), consisting of different junction types, containing tight junctions (TJs), gap junctions (GJs), ectoplasmic specialization (ES) and desmosomes. The BTB is one of the tightest blood-tissue barriers among mammals, which isolating germ cells from hazardous substances and immune cell infiltration during spermatogenesis. Therefore, once the BTB is destroyed, hazardous substances and immune cells will enter seminiferous tubule and cause adversely reproductive effects. In addition, PM2.5 also has shown to cause cells and tissues injury via inducing autophagy, inflammation, sex hormones disorder, and oxidative stress. However, the exact mechanisms of the disruption of the BTB, induced by PM2.5, are still unclear. It is suggested that more research is required to identify the potential mechanisms. In this review, we aim to understand the adverse effects on the BTB after exposure to PM2.5 and explore its potential mechanisms, which provides novel insight into accounting for PM2.5-induced BTB injury.
期刊介绍:
Reviews on Environmental Health (REVEH) is an international peer-reviewed journal that aims to fill the need for publication of review articles on hot topics in the field of environmental health. Reviews on Environmental Health aims to be an inspiring forum for scientists, environmentalists, physicians, engineers, and students who are concerned with aspects of human health, including quality of life, that are determined by physiological and psychosociological interactions between man and physical, chemical, biological, and social factors in the environment.
Reviews on Environmental Health is an important niche served by no other journal, that’s being a site where thoughtful reviews can be published on a variety of subjects related to both health and environment. One challenge is to bridge the research on environmental causes of disease with the clinical practice of medicine. Reviews on Environmental Health is a source of integrated information on environment and health subjects that will be of value to the broad scientific community, whether students, junior and senior professionals, or clinicians.