{"title":"2-氯甲基-3,5-二甲基-4-甲氧基吡啶的合成及分析 Synthesis and Analysis of 2-Chloromethyl-3,5-Dimethyl-4-Methoxypyridine","authors":"陈向莹, 范芳芳, 夏佳美, 张千峰","doi":"10.12677/JOCR.2016.44014","DOIUrl":null,"url":null,"abstract":"以2,3,5-三甲基吡啶为起始原料，经N-氧化、硝化、亲核取代、重排水解和氯甲基化等五大步骤而制得2-氯甲基-3,5-二甲基-4-甲氧基吡啶的合成与工艺。并通过1HNMR、FT-IR、HPLC等测试手段对2-氯甲基-3,5-二甲基-4-甲氧基吡啶产品进行定性和定量分析。 2-Chloromethyl-3,5-dimethyl-4-methoxypyridine was synthesized by use of 2,3,5-trimethylpyridine as the starting material. The synthetic route contains five steps including N-oxidation, nitration, nu-cleophilic substitution, alcoholation and chloromethylation. The target product was qualitatively and quantitatively analyzed using 1H NMR, FT-IR, and HPLC testing methods.","PeriodicalId":16596,"journal":{"name":"Journal of Organic Chemistry Research","volume":"48 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2016-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"2-氯甲基-3,5-二甲基-4-甲氧基吡啶的合成及分析 Synthesis and Analysis of 2-Chloromethyl-3,5-Dimethyl-4-Methoxypyridine\",\"authors\":\"陈向莹, 范芳芳, 夏佳美, 张千峰\",\"doi\":\"10.12677/JOCR.2016.44014\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"以2,3,5-三甲基吡啶为起始原料，经N-氧化、硝化、亲核取代、重排水解和氯甲基化等五大步骤而制得2-氯甲基-3,5-二甲基-4-甲氧基吡啶的合成与工艺。并通过1HNMR、FT-IR、HPLC等测试手段对2-氯甲基-3,5-二甲基-4-甲氧基吡啶产品进行定性和定量分析。 2-Chloromethyl-3,5-dimethyl-4-methoxypyridine was synthesized by use of 2,3,5-trimethylpyridine as the starting material. The synthetic route contains five steps including N-oxidation, nitration, nu-cleophilic substitution, alcoholation and chloromethylation. The target product was qualitatively and quantitatively analyzed using 1H NMR, FT-IR, and HPLC testing methods.\",\"PeriodicalId\":16596,\"journal\":{\"name\":\"Journal of Organic Chemistry Research\",\"volume\":\"48 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-12-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Organic Chemistry Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.12677/JOCR.2016.44014\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Organic Chemistry Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.12677/JOCR.2016.44014","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
以2,3,5-三甲基吡啶为起始原料，经N-氧化、硝化、亲核取代、重排水解和氯甲基化等五大步骤而制得2-氯甲基-3,5-二甲基-4-甲氧基吡啶的合成与工艺。并通过1HNMR、FT-IR、HPLC等测试手段对2-氯甲基-3,5-二甲基-4-甲氧基吡啶产品进行定性和定量分析。 2-Chloromethyl-3,5-dimethyl-4-methoxypyridine was synthesized by use of 2,3,5-trimethylpyridine as the starting material. The synthetic route contains five steps including N-oxidation, nitration, nu-cleophilic substitution, alcoholation and chloromethylation. The target product was qualitatively and quantitatively analyzed using 1H NMR, FT-IR, and HPLC testing methods.
2-氯甲基-3,5-二甲基-4-甲氧基吡啶的合成及分析 Synthesis and Analysis of 2-Chloromethyl-3,5-Dimethyl-4-Methoxypyridine
以2,3,5-三甲基吡啶为起始原料，经N-氧化、硝化、亲核取代、重排水解和氯甲基化等五大步骤而制得2-氯甲基-3,5-二甲基-4-甲氧基吡啶的合成与工艺。并通过1HNMR、FT-IR、HPLC等测试手段对2-氯甲基-3,5-二甲基-4-甲氧基吡啶产品进行定性和定量分析。 2-Chloromethyl-3,5-dimethyl-4-methoxypyridine was synthesized by use of 2,3,5-trimethylpyridine as the starting material. The synthetic route contains five steps including N-oxidation, nitration, nu-cleophilic substitution, alcoholation and chloromethylation. The target product was qualitatively and quantitatively analyzed using 1H NMR, FT-IR, and HPLC testing methods.
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