变形虫Rab GTPase基因家族的系统发育重建与进化。

Q2 Biochemistry, Genetics and Molecular Biology
Alfredo L Porfírio-Sousa, Alexander K Tice, Matthew W Brown, Daniel J G Lahr
{"title":"变形虫Rab GTPase基因家族的系统发育重建与进化。","authors":"Alfredo L Porfírio-Sousa,&nbsp;Alexander K Tice,&nbsp;Matthew W Brown,&nbsp;Daniel J G Lahr","doi":"10.1080/21541248.2021.1903794","DOIUrl":null,"url":null,"abstract":"<p><p>Rab GTPase is a paralog-rich gene family that controls the maintenance of the eukaryotic cell compartmentalization system. Diverse eukaryotes have varying numbers of Rab paralogs. Currently, little is known about the evolutionary pattern of Rab GTPase in most major eukaryotic 'supergroups'. Here, we present a comprehensive phylogenetic reconstruction of the Rab GTPase gene family in the eukaryotic 'supergroup' Amoebozoa, a diverse lineage represented by unicellular and multicellular organisms. We demonstrate that Amoebozoa conserved 20 of the 23 ancestral Rab GTPases predicted to be present in the last eukaryotic common ancestor and massively expanded several 'novel' in-paralogs. Due to these 'novel' in-paralogs, the Rab family composition dramatically varies between the members of Amoebozoa; as a consequence, 'supergroup'-based studies may significantly change our current understanding of the evolution and diversity of this gene family. The high diversity of the Rab GTPase gene family in Amoebozoa makes this 'supergroup' a key lineage to study and advance our knowledge of the evolution of Rab in Eukaryotes.</p>","PeriodicalId":22139,"journal":{"name":"Small GTPases","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/21541248.2021.1903794","citationCount":"1","resultStr":"{\"title\":\"Phylogenetic reconstruction and evolution of the Rab GTPase gene family in Amoebozoa.\",\"authors\":\"Alfredo L Porfírio-Sousa,&nbsp;Alexander K Tice,&nbsp;Matthew W Brown,&nbsp;Daniel J G Lahr\",\"doi\":\"10.1080/21541248.2021.1903794\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Rab GTPase is a paralog-rich gene family that controls the maintenance of the eukaryotic cell compartmentalization system. Diverse eukaryotes have varying numbers of Rab paralogs. Currently, little is known about the evolutionary pattern of Rab GTPase in most major eukaryotic 'supergroups'. Here, we present a comprehensive phylogenetic reconstruction of the Rab GTPase gene family in the eukaryotic 'supergroup' Amoebozoa, a diverse lineage represented by unicellular and multicellular organisms. We demonstrate that Amoebozoa conserved 20 of the 23 ancestral Rab GTPases predicted to be present in the last eukaryotic common ancestor and massively expanded several 'novel' in-paralogs. Due to these 'novel' in-paralogs, the Rab family composition dramatically varies between the members of Amoebozoa; as a consequence, 'supergroup'-based studies may significantly change our current understanding of the evolution and diversity of this gene family. The high diversity of the Rab GTPase gene family in Amoebozoa makes this 'supergroup' a key lineage to study and advance our knowledge of the evolution of Rab in Eukaryotes.</p>\",\"PeriodicalId\":22139,\"journal\":{\"name\":\"Small GTPases\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1080/21541248.2021.1903794\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Small GTPases\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/21541248.2021.1903794\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Biochemistry, Genetics and Molecular Biology\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Small GTPases","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/21541248.2021.1903794","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 1

摘要

Rab GTPase是一个富含旁系的基因家族,控制着真核细胞区隔系统的维持。不同的真核生物有不同数量的拉布类似物。目前,关于Rab GTPase在大多数主要真核“超群”中的进化模式知之甚少。在这里,我们提出了一个全面的系统发育重建Rab GTPase基因家族在真核“超群”阿米巴虫,一个多样化的谱系代表单细胞和多细胞生物。我们证明阿米巴原虫保存了23个祖先Rab gtpase中的20个,这些酶被预测存在于最后的真核共同祖先中,并大规模扩展了几个“新的”相似物。由于这些“新颖”的同源性,变形虫的成员之间Rab家族的组成发生了巨大的变化;因此,基于“超群”的研究可能会显著改变我们目前对这个基因家族的进化和多样性的理解。变形虫中Rab GTPase基因家族的高度多样性使这个“超群”成为研究和推进我们对真核生物Rab进化知识的关键谱系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Phylogenetic reconstruction and evolution of the Rab GTPase gene family in Amoebozoa.

Phylogenetic reconstruction and evolution of the Rab GTPase gene family in Amoebozoa.

Phylogenetic reconstruction and evolution of the Rab GTPase gene family in Amoebozoa.

Rab GTPase is a paralog-rich gene family that controls the maintenance of the eukaryotic cell compartmentalization system. Diverse eukaryotes have varying numbers of Rab paralogs. Currently, little is known about the evolutionary pattern of Rab GTPase in most major eukaryotic 'supergroups'. Here, we present a comprehensive phylogenetic reconstruction of the Rab GTPase gene family in the eukaryotic 'supergroup' Amoebozoa, a diverse lineage represented by unicellular and multicellular organisms. We demonstrate that Amoebozoa conserved 20 of the 23 ancestral Rab GTPases predicted to be present in the last eukaryotic common ancestor and massively expanded several 'novel' in-paralogs. Due to these 'novel' in-paralogs, the Rab family composition dramatically varies between the members of Amoebozoa; as a consequence, 'supergroup'-based studies may significantly change our current understanding of the evolution and diversity of this gene family. The high diversity of the Rab GTPase gene family in Amoebozoa makes this 'supergroup' a key lineage to study and advance our knowledge of the evolution of Rab in Eukaryotes.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Small GTPases
Small GTPases Biochemistry, Genetics and Molecular Biology-Biochemistry
CiteScore
6.10
自引率
0.00%
发文量
6
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信