肥胖母亲脐带血ILDR2的表观遗传调控

B.P. Larkin , L.T. Nguyen , S.J. Glastras , M. Gangadharan Komala , C.A. Pollock , S. Saad
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引用次数: 0

摘要

包括DNA甲基化在内的表观遗传修饰已被证明与胎儿疾病的编程有关。先前的动物研究表明,ILDR2基因表达降低与糖尿病、血脂异常和肝脂肪变性有关。使用来自肥胖和正常体重母亲的胎儿脐带血,我们发现了ILDR2基因甲基化的差异。这与ILDR2 mRNA表达的显著变化和新生儿体重的变化有关。我们的研究结果表明,肥胖母亲的后代代谢后果的风险增加,ILDR2基因的表观遗传调控可能参与其中。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Epigenetic regulation of ILDR2 in the cord blood of obese mothers

Epigenetic modifications including DNA methylation have been shown to be involved in the fetal programming of disease. Previous animal studies have shown that reduced expression of the ILDR2 gene is associated with diabetes, dyslipidaemia and hepatic steatosis. Using fetal cord blood from obese and normal weight mothers, we identified differential methylation of the ILDR2 gene. This was associated with significant changes in ILDR2 mRNA expression, and changes in neonatal body weight. Our findings suggest that the offspring of obese mothers are at increased risk of metabolic consequences, and that epigenetic regulation of the ILDR2 gene may be involved.

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