Natural Compounds to Counteract Testosterone Depletion in Aging

Aging is accompanied by many biological and physiological changes in the body, including the depletion of sex hormones such as testosterone. Testosterone is an important sex hormone for many physiological and biological functions in the body, and depletion of it may cause changes that can be negative to the normal functioning of the body. Aging is associated with a gradual depletion of testosterone of about 2-3% annually, starting from the age of 30 [1]. This depletion of the sex hormones has many implications in the physiological functions in the body, such as effects in muscle mass, liver function and immune function [2]. These negative effects can render the body susceptible to diseases and many adverse symptoms. Testosterone depletion is also associated with vulnerability to disease in hormone-responsive tissues, such as the brain, and it has been seen that androgens and estrogens have very beneficial effects in increasing spine density and synaptic plasticity [1]. This is a key subject to be researched as there have been studies that found a relationship between brain level in testosterone and levels of soluble Amyloid Beta, indicating a correlation between hormone depletion and risk of neurodegenerative diseases [3]. It is important to find this relationship and find new and novel ways to counteract this testosterone depletion in a way that is natural, risk-free, and cost effective.