蚕豆籽和橙皮提取物对微囊藻毒素LR对大鼠血清钙、磷酸盐的影响具有保护作用

European Journal of Biological Research Pub Date : 2020-07-11 DOI:10.5281/ZENODO.3940650

B. D. Srivastava, M. Srivastava, S. Srivastav, M. Urata, N. Suzuki, A. Srivastav

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引用次数: 1

摘要

Wistar大鼠作为A组:对照组;B组:微囊藻毒素LR (MCLR);C组:微囊藻毒素LR和榛子提取物(MCLR+JSE);D组:微囊藻毒素LR和橙皮提取物(MCLR+OPE);E组:橙皮提取物(OPE);F组:jamun种子提取物(JSE)。MCLR剂量为10µg/kg体重量/天，而OPE和JSE剂量为200 mg/kg体重量/天。第15天和第30天测定血清钙和磷酸盐。MCLR暴露15 d大鼠血清钙;MCLR+JSE和MCLR+OPE降低。虽然C组和D组的钙水平几乎没有增加，但用OPE和JSE治疗并不能完全恢复MCLR引起的钙水平下降。30 d后，MCLR后钙含量下降;MCLR+JSE和MCLR+OPE治疗。E组和F组的水平保持不变。与B组相比，C组和D组的钙水平升高，这表明使用OPE和JSE治疗可以恢复钙。MCLR患者15天后血清磷酸盐下降;MCLR+JSE和MCLR+OPE治疗大鼠。C组(与F组相比)和D组(与E组相比)的磷酸盐水平均下降。暴露于MCLR 30天后;MCLR+JSE和MCLR+OPE的磷酸盐水平降低。与B组相比，C组和D组的水平升高。C组(与F组相比)和D组(与E组相比)的磷酸盐水平均降低。这表明OPE和JSE处理使磷酸盐水平有所恢复。DOI: http://dx.doi.org/10.5281/zenodo.3940650

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Jamun seed and orange peel extracts protects effects of microcystin LR on serum calcium and phosphate of rats

Wistar rats were treated as Group A: Control; Group B: microcystin LR (MCLR); Group C: microcystin LR and jamun seed extract (MCLR+JSE); Group D: microcystin LR and orange peel extract (MCLR+OPE); Group E: orange peel extract (OPE); Group F: jamun seed extract (JSE). MCLR dose was 10 µg/kg body wt/day whereas OPE and JSE dose was 200 mg/kg body wt/day. Serum calcium and phosphate were analyzed on 15 and 30 day. Serum calcium of rat exposed for 15 day to MCLR; MCLR+JSE and MCLR+OPE decreased. Although there is little increase in levels of group C and group D but treatment with OPE and JSE is not able to completely restore decreased calcium levels caused by MCLR. After 30 day calcium decreased after MCLR; MCLR+JSE and MCLR+OPE treatment. Levels in group E and F remain unaltered. Levels in group C and D exhibit elevation as compared to group B which indicates that treatment with OPE and JSE recovered calcium. Serum phosphate decreased after 15 day in MCLR; MCLR+JSE and MCLR+OPE treated rats. Phosphate levels of group C (compared with group F) and group D (compared with group E) show decrease. After 30 day exposure to MCLR; MCLR+JSE and MCLR+OPE phosphate levels decreased. Levels of group C and D when compared with group B are increased. Phosphate levels of group C (compared with group F) and D (compared with group E) are decreased. This indicates that OPE and JSE treatment provoked some recovery of phosphate levels. DOI: http://dx.doi.org/10.5281/zenodo.3940650

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European Journal of Biological Research

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