西非多哥lomoise校园教学医院高血压患者与可改变心血管危险因素相关的降压药物治疗方案

Y. Potchoo, E. Goeh-Akue, F. Damorou, Stéphane Lolognier, Barima Massoka, D. Redah, I. Guissou
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引用次数: 0

摘要

目的:本前瞻性研究旨在针对高血压患者中与压力和久坐生活方式、肥胖、糖尿病和慢性乙基化等可变心血管危险因素相关的高血压药物治疗方案。材料与方法:本研究在校园教学医院心内科就诊的伴有合并症(压力大、久坐生活方式、肥胖、糖尿病和乙基化)的高血压患者中进行,并给予降压药物治疗。结果:112例HBP患者中,43例(38.39%)接受了门诊治疗,69例(61.61%)住院。43例门诊患者中存在2、3和≥4个可改变危险因素的比例分别为37.21%和18.60%,69例住院患者中存在2、3和≥4个可改变危险因素的比例分别为24.64%、34.78%和23.19%。关于所接受的降压药方案和患者的相关危险因素,观察到有3种危险因素的患者收缩压(SBP)显著降低,至少有慢性乙基化(压力、久坐生活方式、肥胖和糖尿病中的另一危险因素)的患者舒张压(DBP)显著降低。在合并高血压的病例中,针对高压力、久坐生活方式和肥胖的住院患者,对伴有3种危险因素的门诊患者,将利尿剂(D)、钙通道拮抗剂(CCA)和血管紧张素转换酶抑制剂(ACEI)作为单药治疗的首选,或在处方总组合的2/3中,在适当的组合中添加中央作用降压药(CAAD)。结论:降压药方案从单药到四药治疗可显著控制伴有3种可改变危险因素的患者的收缩压,以及至少伴有慢性乙基化(应激、久坐、肥胖和糖尿病中的另一危险因素)的患者的舒张压。对于伴有可改变危险因素的复杂高血压,除CAAD外,D或CCA或ACEI或适当的组合是最受欢迎的药理学组。引用本文:Potchoo Y, Goeh-Akue E, Damorou F, Lolognier S, Massoka B,等。(2018)西非多哥lomoreit校园教学医院高血压患者高血压相关心血管危险因素的降压药物治疗方案。医药科学:JPPS-176。2574 - 7711 . DOI: 10.29011 /。100076 2卷2018;第03期《J Pharma pharmra Sci》,开放获取期刊ISSN: 2474-7711
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antihypertensive Drug Regimen for High Blood Pressure Associated with Modifiable Cardiovascular Risk Factors Among Hypertensive Patients Attending Campus Teaching Hospital of Lomé, Togo, West Africa
Objective: The present prospective study was aimed to target the antihypertensive drug regimen for HBP associated with modifiable cardiovascular risk factors such as stressful and sedentary lifestyle, obesity, diabetes and chronic ethylism among hypertensive patients. Material and Method: This study was conducted among outpatients and inpatients attending the department of cardiology of Campus Teaching Hospital for hypertension conditions associated with comorbidities (stressful, sedentary lifestyle, obesity, diabetes and ethylism) and placed on antihypertensive drug therapy. Results: Of the 112 patients treated for HBP, 43 (38.39%) received an ambulatory treatment and 69 (61.61%) were hospitalized. Of 43 outpatients, 37.21% and 18.60% vs 24.64%, 34.78% and 23.19% of 69 inpatients presented respectively 2, 3 and ≥ 4 concomitant modifiable risk factors. Regarding the antihypertensive drug regimens received and concomitant risk factor profile of patients, significant reduction of Systolic Blood Pressure (SBP) among patients with 3 risk factors and Diastolic Blood Pressure (DBP) among patients with at least, together with chronic ethylism, another risk factor among stressful, sedentary lifestyle, obesity and diabetes, was observed. In cases of complicated HBP, outpatients with 3 concomitant risk factors against inpatients with high stress, sedentary lifestyle and obesity were placed on diuretic (D), Calcium Channel Antagonist (CCA) and Angiotensin Converting Enzyme Inhibitor (ACEI) as first choice in monotherapy or in addition to Centrally Acting Antihypertensive Drug (CAAD) in suitable combinations in 2/3 of total combinations prescribed. Conclusion: antihypertensive drug regimens from mono to quadruple therapy allowed to control significantly SBP in patients with 3 concomitant modifiable risk factors and DBP among patients with at least, together with chronic ethylism, another risk factor among stress, sedentarity, obesity and diabetes. In complicated HBP with concomitant modifiable risk factors, D or CCA or ACEI or in suitable combinations in addition to CAAD were the favorite pharmacological groups prescribed. Citation: Potchoo Y, Goeh-Akue E, Damorou F, Lolognier S, Massoka B, et al. (2018) Antihypertensive Drug Regimen for High Blood Pressure Associated with Modifiable Cardiovascular Risk Factors Among Hypertensive Patients Attending Campus Teaching Hospital of Lomé, Togo, West Africa. J Pharma Pharma Sci: JPPS-176. DOI: 10.29011/2574-7711. 100076 2 Volume 2018; Issue 03 J Pharma Phamra Sci, an open access journal ISSN: 2474-7711
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