Caizhe Yang, Yajing Yu, Xian-rong Xu, Jun Zheng, Hongjin Liu, Zhao-jun Fu, Li Cui, Xiaohong Guan
{"title":"飞行员胺碘酮致甲状腺功能障碍2例并文献复习","authors":"Caizhe Yang, Yajing Yu, Xian-rong Xu, Jun Zheng, Hongjin Liu, Zhao-jun Fu, Li Cui, Xiaohong Guan","doi":"10.3760/CMA.J.ISSN.1007-6239.2015.02.007","DOIUrl":null,"url":null,"abstract":"Objective \nTo summarize the clinic feature, diagnosis, treatment, and prognosis of amiodarone-induced thyroid dysfunction in the pilots with arrhythmia and gather the experiences on treatment and aviation medical assessment. \n \n \nMethods \nRetrospective analysis was done on the process of 2 cases with amiodarone induced abnormal thyroid function in pilots with atrial fibrillation and on the literatures to summary the clinic feature, diagnosis, treatment, and prognosis were reviewed. \n \n \nResults \nCase 1 had taken amiodarone for 7 months and low T3 syndrome was diagnosed 1 month later. Two years later, he took amiodarone again for 1 month and was induced type 2 thyrotoxicosis iodine. After he stopped taking amiodarone for 3 months his thyroid function returned to normal. Case 2 was diagnosed iodine induced hypothyroidism after intermittent taking amiodarone for 9 years. The patient changed to the treatment with 75 μg levothyroxine daily for 5 months and his thyroid function was in normal. By 2-year levothyroxine treatment his thyroid function completely recovered. Aviation medical assessment of two pilots is temporary dlisqualified as arrhythmias. \n \n \nConclusions \nThe thyroid related examination is necessary before taking amiodarone. In the treatment of amiodarone, or after withdrawal for 6-9 months or even longer, the regular follow-up is suggested, especially for the patients with thyroid diseases history and with risk factors. Amiodarone-induced abnormal thyroid function could be treated. The aviation medical assessment should be concerned arrhythmias and thyroid function. \n \n \nKey words: \nAmiodarone; Thyrotoxicosis; Hypothyroidism; Diagnosis; Treatment outcome; Pilots","PeriodicalId":9904,"journal":{"name":"中华航空航天医学杂志","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2015-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Two cases of pilots with amiodarone-induced thyroid dysfunction and literature review\",\"authors\":\"Caizhe Yang, Yajing Yu, Xian-rong Xu, Jun Zheng, Hongjin Liu, Zhao-jun Fu, Li Cui, Xiaohong Guan\",\"doi\":\"10.3760/CMA.J.ISSN.1007-6239.2015.02.007\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective \\nTo summarize the clinic feature, diagnosis, treatment, and prognosis of amiodarone-induced thyroid dysfunction in the pilots with arrhythmia and gather the experiences on treatment and aviation medical assessment. \\n \\n \\nMethods \\nRetrospective analysis was done on the process of 2 cases with amiodarone induced abnormal thyroid function in pilots with atrial fibrillation and on the literatures to summary the clinic feature, diagnosis, treatment, and prognosis were reviewed. \\n \\n \\nResults \\nCase 1 had taken amiodarone for 7 months and low T3 syndrome was diagnosed 1 month later. Two years later, he took amiodarone again for 1 month and was induced type 2 thyrotoxicosis iodine. After he stopped taking amiodarone for 3 months his thyroid function returned to normal. Case 2 was diagnosed iodine induced hypothyroidism after intermittent taking amiodarone for 9 years. The patient changed to the treatment with 75 μg levothyroxine daily for 5 months and his thyroid function was in normal. By 2-year levothyroxine treatment his thyroid function completely recovered. Aviation medical assessment of two pilots is temporary dlisqualified as arrhythmias. \\n \\n \\nConclusions \\nThe thyroid related examination is necessary before taking amiodarone. In the treatment of amiodarone, or after withdrawal for 6-9 months or even longer, the regular follow-up is suggested, especially for the patients with thyroid diseases history and with risk factors. Amiodarone-induced abnormal thyroid function could be treated. 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Two cases of pilots with amiodarone-induced thyroid dysfunction and literature review
Objective
To summarize the clinic feature, diagnosis, treatment, and prognosis of amiodarone-induced thyroid dysfunction in the pilots with arrhythmia and gather the experiences on treatment and aviation medical assessment.
Methods
Retrospective analysis was done on the process of 2 cases with amiodarone induced abnormal thyroid function in pilots with atrial fibrillation and on the literatures to summary the clinic feature, diagnosis, treatment, and prognosis were reviewed.
Results
Case 1 had taken amiodarone for 7 months and low T3 syndrome was diagnosed 1 month later. Two years later, he took amiodarone again for 1 month and was induced type 2 thyrotoxicosis iodine. After he stopped taking amiodarone for 3 months his thyroid function returned to normal. Case 2 was diagnosed iodine induced hypothyroidism after intermittent taking amiodarone for 9 years. The patient changed to the treatment with 75 μg levothyroxine daily for 5 months and his thyroid function was in normal. By 2-year levothyroxine treatment his thyroid function completely recovered. Aviation medical assessment of two pilots is temporary dlisqualified as arrhythmias.
Conclusions
The thyroid related examination is necessary before taking amiodarone. In the treatment of amiodarone, or after withdrawal for 6-9 months or even longer, the regular follow-up is suggested, especially for the patients with thyroid diseases history and with risk factors. Amiodarone-induced abnormal thyroid function could be treated. The aviation medical assessment should be concerned arrhythmias and thyroid function.
Key words:
Amiodarone; Thyrotoxicosis; Hypothyroidism; Diagnosis; Treatment outcome; Pilots
期刊介绍:
The aim of Chinese Journal of Aerospace Medicine is to combine theory and practice, improve and popularize, actively advocate a hundred flowers bloom and a hundred schools of thought contend, advocate seeking truth from facts, promote the development of the related disciplines of aerospace medicine and human efficiency, and promote the exchange and penetration of aerospace medicine and human efficiency with other biomedical and engineering specialties.
Topics of interest for Chinese Journal of Aerospace Medicine include:
-The content of the journal belongs to the discipline of special medicine and military medicine, with the characteristics of multidisciplinary synthesis and cross-penetration, and mainly reflected in the aerospace industry, aerospace flight safety and efficiency, as well as the synthesis of special medicine, preventive medicine, environmental medicine, psychology, etc.
-Military aeromedicine (Air Force, Navy and Army aeromedicine) and civil aeromedicine, with a balance of aerospace medicine are the strengths of the journal.
-The change in aerospace medicine from a focus on promoting physiological compensatory adaptations to enhancing human performance under extreme environmental conditions is what the journal is helping to promote.
-The expansion of manuscripts in high altitude medicine is also a special emphasis of the journal.