脂溢性皮炎:局部治疗策略的选择,考虑到皮肤微生物组的特点

N. Reznichenko, Y. Reznichenko, O. Veretelnyk
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摘要

目的:探讨倍他理、曲库坦和Psoricap治疗脂溢性皮炎的临床疗效和安全性。材料和方法。研究纳入75例脂溢性皮炎患者(主要组)。对照组由56名同年龄的健康个体组成。脂溢性皮炎患者的严重程度采用点量表进行评估,包括红斑、水肿、渗出病变、擦伤、脱屑、皮肤油腻程度的评估。采用直接定性和定量评价的方法对皮肤微生物病进行研究。焦虑水平采用斯皮尔伯格-哈宁自评量表进行评估。根据建议的治疗方法,将脂溢性皮炎患者分为两组:第一组(实验组)- 43例患者接受倍他利康治疗5天,曲acutan治疗5天,Psoricap治疗18天,从治疗第11天开始;第二组(对照组)- 32例接受局部皮质类固醇治疗的患者。结果和讨论。脂溢性皮炎病程伴有皮肤微生物病,受影响地区马拉色菌属和念珠菌属真菌数量增加,需要适当治疗。脂溢性皮炎患者的特点是存在高度的个人和情境焦虑。在脂溢性皮炎的标准治疗中纳入倍他力和曲acutan有助于大多数患者的康复,并在不同部位的病理过程中有显着改善。与实验亚组相比,在标准治疗的亚组中,这些比率明显较低。在脂溢性皮炎患者的治疗方案中额外加入Psoricap,导致头皮和面部病理过程定位的患者100%恢复。结论。使用Betasalic软膏、Triacutan软膏或软膏和Psoricap软膏对脂溢性皮炎的综合治疗在病理学上得到了证明,因为它提供了快速的临床效果,使皮肤微生物病正常化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Seborrheic dermatitis: the choice of topical treatment tactics, taking into account the characteristics of the skin microbiome
Objective — to study the clinical efficacy and safety of Betasalic, Triacutan and Psoricap drugs in the treatment of patients with seborrheic dermatitis. Materials and methods. The study included 75 patients with seborrheic dermatitis (main group). The control group consisted of 56 healthy individuals of the same age. The severity of seborrheic dermatitis in patients was assessed on a point scale, which included the assessment of the intensity of erythema, edema, oozing lesions, excoriation, scaling, skin oiliness. The study of skin microbiocenosis was carried out by the method of its direct qualitative and quantitative assessment. The level of anxiety was assessed using the Spielberger—Khanin self-assessment scale. Depending on the proposed treatment, patients with seborrheic dermatitis were divided into 2 groups: Group I (experimental group) — 43 patients who received Betasalic for 5 days, Triacutan — for 5 days, Psoricap — for 18 days starting from the 11th day of therapy; Group II (comparison group) — 32 patients who received topical corticosteroids. Results and discussion. The course of seborrheic dermatitis is accompanied by disorders of the skin microbiocenosis with an increase in the number of fungi of Malassezia and Candida genus in the affected areas, which requires appropriate treatment. Patients with seborrheic dermatitis are characterized by the presence of high personal and situational anxiety. The inclusion of Betasalic and Triacutan in the standard therapy of seborrheic dermatitis contributed to the recovery of the majority of patients and a significant improvement in different localizations of the pathological process. In contrast to the experimental subgroup, in the subgroup with standard treatment, these rates were significantly lower. Additional inclusion of Psoricap in the treatment regimen of patients with seborrheic dermatitis led to the recovery of 100 % of patients with the localization of the pathological process on the scalp and face. Conclusions. Complex therapy of seborrheic dermatitis with the use of Betasalic ointment, Triacutan cream or ointment and Psoricap cream is pathogenetically proved, since it provides a quick clinical effect, normalization of skin microbiocenosis.
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