半导体量子点作为智能生物相容显像剂

J. M. Baruah, J. Narayan
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引用次数: 0

摘要

胶体量子点(CQDs)正在成为一个吸引人的平台,作为光学成像的一类令人兴奋的荧光探针,因为它们具有可调和独特的光学特性,高稳定性和靶向受影响组织的能力,与小分子有机染料相比,基于它们的表面功能化。更令人同情的是,目前的染料缺乏最佳性能所需的信号穿透,组织规范,代谢系统稳定性和光漂白电阻率特性。因此,半导体量子点代表了一类令人兴奋的发光材料,具有良好的荧光特性,如窄发射带;高效的斯托克斯位移和长荧光寿命。最具体地说,可以通过改变量子点的尺寸、尺寸分布和晶体结构来实现从紫外蓝到中红外发射的可调谐荧光,以保持高分辨率,从而实现更深层次的成像。这些潜在的性质使得量子点适合作为现有染料的直接替代品。在过去的5-6年中,荧光量子点作为生物领域探针的应用正在兴起,作为智能生物医学成像、生物标记和药物递送剂,这是一种非常有前途的技术,因为荧光技术具有很高的灵敏度。然而,由于量子点的毒性是一个非常值得关注的问题,因此,是否将量子点作为当今药物伴生物/染料的未来继承人仍然是一个困惑的问题。毒性已成为量子点不可分割的一部分,主要是由于a)非表面钝化,b)氧化降解,c)生物相容性差以及d)选择非生物相容性封盖剂。因此,人们正在努力消除这些威胁,仅在合成部分,通过表面功能化具有更好的生物相容性和细胞友好性的量子点。由于这些量子点在细菌接触时可以自给自足地治愈任何细菌生长,鉴于它们在生物系统中作为标记,成像和抗菌剂具有巨大的潜在应用,本工作报道了表面修饰的半导体量子点的制备,表征和生物相容性,以建立它们在卫生和医疗领域的高效荧光探针。胶体量子点(CQDs)正在成为一个吸引人的平台,作为光学成像的一类令人兴奋的荧光探针,因为它们具有可调和独特的光学特性,高稳定性和靶向受影响组织的能力,与小分子有机染料相比,基于它们的表面功能化。更令人同情的是,目前的染料缺乏最佳性能所需的信号穿透,组织规范,代谢系统稳定性和光漂白电阻率特性。因此,半导体量子点代表了一类令人兴奋的发光材料,具有良好的荧光特性,如窄发射带;高效的斯托克斯位移和长荧光寿命。最具体地说,可以通过改变量子点的尺寸、尺寸分布和晶体结构来实现从紫外蓝到中红外发射的可调谐荧光,以保持高分辨率,从而实现更深层次的成像。这些潜在的性质使得量子点适合…
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Semiconductor quantum dots as smart biocompatible imaging agents
Colloidal quantum dots (CQDs) are coming up as appealing platform, as exciting class of fluorescent probes for optical imaging, because of their tunable and unique optical properties, high stability and ability to target affected tissue, based on their surface functionalization compared to small molecules of organic dyes. More empathetically, it has been observed that the current dyes lack the signal penetration needed for optimal performance, the tissue specification, and stability in metabolic systems and photo bleaching resistivity properties. Thus, semiconducting QDs represent an exciting class of luminescent materials with favourable fluorescent properties like narrow emission band; efficient stokes shift and long fluorescent lifetime. Most specifically, tunable fluorescence ranging from UV-blue to the mid infrared emission to maintain high resolution for deeper imaging can be achieved by altering the size, size distribution and crystal structure of the QDs. These potential properties make QDs suitable as direct substitutes for the existing dyes. From the last 5-6 years, the application of fluorescent QDs, as probes for biological domain are emerging as smart bio-medical imaging, bio-tagging and drug delivery agents leading to a highly promising technique as fluorescent based techniques are very sensitive. However, decision of making QDs as the future heir of the present day drug associates/dyes, is still perplexed as their toxicity is a matter of great concern. Toxicity has become an integral part of QDs mainly due to a) non-surface passivation, b) oxidative degradation, c) poor biocompatibility and d) choosing of nonbiocompatible capping agents. Therefore efforts are going on to neutralize these threats during the synthesis part only, by surface functionalizing the QDs with better biocompatibility and cytofriendlyness. Since, these QDs are self-sufficient to heal any bacterial growth when bacteria are in touch with them, keeping in view of having tremendous potential application as tagging, imaging and antibacterial agents in biological systems, the present work reports the preparation, characterization and biocompatibility of semiconducting QDs with surface modifications to establish them as efficient fluorescent probes in health and medical sector.Colloidal quantum dots (CQDs) are coming up as appealing platform, as exciting class of fluorescent probes for optical imaging, because of their tunable and unique optical properties, high stability and ability to target affected tissue, based on their surface functionalization compared to small molecules of organic dyes. More empathetically, it has been observed that the current dyes lack the signal penetration needed for optimal performance, the tissue specification, and stability in metabolic systems and photo bleaching resistivity properties. Thus, semiconducting QDs represent an exciting class of luminescent materials with favourable fluorescent properties like narrow emission band; efficient stokes shift and long fluorescent lifetime. Most specifically, tunable fluorescence ranging from UV-blue to the mid infrared emission to maintain high resolution for deeper imaging can be achieved by altering the size, size distribution and crystal structure of the QDs. These potential properties make QDs suitab...
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