印度南部人类免疫缺陷病毒感染儿童微量营养素状况

IF 0.3 Q4 INFECTIOUS DISEASES
Sangeetha Sivasubramanian, J. Shenoy, S. Kamath, V. Kulkarni, Mukund P. Srinivasan, B. S. Baliga
{"title":"印度南部人类免疫缺陷病毒感染儿童微量营养素状况","authors":"Sangeetha Sivasubramanian, J. Shenoy, S. Kamath, V. Kulkarni, Mukund P. Srinivasan, B. S. Baliga","doi":"10.5114/hivar.2020.93062","DOIUrl":null,"url":null,"abstract":"Introduction: Deficiencies of micronutrients play a role in human immunodeficiency virus (HIV) infection and its severity. Identifying the micronutrient status would guide supplementation, thus al-tering the disease progression and severity. Material and methods: A cross-sectional hospital-based study was conducted in Southern India on hundred HIV-infected children. Estimation of serum micronutrient levels (zinc, copper, and iron) and comparison of the deficient micronutrients with clinical stages, immunological categories, CD4 counts, and nutritional status was performed. Results: Among 100 HIV-infected children, zinc deficiency was the most common (62%), whereas copper and iron deficiency was present in 2% and 1%, respectively. Mean age of children was 11.20 ± 3.14 years, 52% were girls, 24% were malnourished, 76% were receiving antiretroviral therapy (ART), and four had CD4 counts < 200/mm 2 indicating AIDS. Using Kruskalwallis test, serum iron levels ( p = 0.000) and CD4 levels ( p = 0.001) were significantly associated with clinical stages, while serum zinc levels ( p = 0.043) and CD4 levels ( p = 0.000) were significantly associated with various degrees of immune classification. Mean micronutrient levels did not correlate significantly with CD4 counts less than and greater than 350 by unpaired t test. Zinc deficiency did not correlate with clinical staging, immunological classification, nutritional status, and receipt of ART on multiple logistic regression analysis. Conclusion: In HIV-infected children, zinc deficiency was the most common and it did not correlate with clinical staging, immunological classification, nutritional status, and receipt of antiretroviral therapy. Hence, supplementation of zinc would be required along with initiation of ART.","PeriodicalId":53943,"journal":{"name":"HIV & AIDS Review","volume":null,"pages":null},"PeriodicalIF":0.3000,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Micronutrients status among human immunodeficiency virus-infected children in Southern India\",\"authors\":\"Sangeetha Sivasubramanian, J. Shenoy, S. Kamath, V. Kulkarni, Mukund P. Srinivasan, B. S. Baliga\",\"doi\":\"10.5114/hivar.2020.93062\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Introduction: Deficiencies of micronutrients play a role in human immunodeficiency virus (HIV) infection and its severity. Identifying the micronutrient status would guide supplementation, thus al-tering the disease progression and severity. Material and methods: A cross-sectional hospital-based study was conducted in Southern India on hundred HIV-infected children. Estimation of serum micronutrient levels (zinc, copper, and iron) and comparison of the deficient micronutrients with clinical stages, immunological categories, CD4 counts, and nutritional status was performed. Results: Among 100 HIV-infected children, zinc deficiency was the most common (62%), whereas copper and iron deficiency was present in 2% and 1%, respectively. Mean age of children was 11.20 ± 3.14 years, 52% were girls, 24% were malnourished, 76% were receiving antiretroviral therapy (ART), and four had CD4 counts < 200/mm 2 indicating AIDS. Using Kruskalwallis test, serum iron levels ( p = 0.000) and CD4 levels ( p = 0.001) were significantly associated with clinical stages, while serum zinc levels ( p = 0.043) and CD4 levels ( p = 0.000) were significantly associated with various degrees of immune classification. Mean micronutrient levels did not correlate significantly with CD4 counts less than and greater than 350 by unpaired t test. Zinc deficiency did not correlate with clinical staging, immunological classification, nutritional status, and receipt of ART on multiple logistic regression analysis. Conclusion: In HIV-infected children, zinc deficiency was the most common and it did not correlate with clinical staging, immunological classification, nutritional status, and receipt of antiretroviral therapy. Hence, supplementation of zinc would be required along with initiation of ART.\",\"PeriodicalId\":53943,\"journal\":{\"name\":\"HIV & AIDS Review\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.3000,\"publicationDate\":\"2020-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"HIV & AIDS Review\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5114/hivar.2020.93062\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"HIV & AIDS Review","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5114/hivar.2020.93062","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 3

摘要

微量营养素缺乏在人类免疫缺陷病毒(HIV)感染及其严重程度中起着重要作用。确定微量营养素状态将指导补充,从而控制疾病的进展和严重程度。材料和方法:在印度南部对100名感染艾滋病毒的儿童进行了一项以医院为基础的横断面研究。评估血清微量营养素水平(锌、铜和铁),并将缺乏微量营养素与临床分期、免疫分类、CD4计数和营养状况进行比较。结果:在100名感染艾滋病毒的儿童中,缺锌最为常见(62%),而铜和铁缺乏症分别占2%和1%。儿童平均年龄为11.20±3.14岁,女童占52%,营养不良占24%,接受抗逆转录病毒治疗(ART)者占76%,CD4计数< 200/ mm2者占4例,提示艾滋病。Kruskalwallis试验显示,血清铁水平(p = 0.000)和CD4水平(p = 0.001)与临床分期显著相关,血清锌水平(p = 0.043)和CD4水平(p = 0.000)与不同程度的免疫分级显著相关。通过非配对t检验,平均微量营养素水平与CD4计数小于或大于350无显著相关性。在多元逻辑回归分析中,锌缺乏与临床分期、免疫分类、营养状况和接受抗逆转录病毒治疗无关。结论:在hiv感染儿童中,锌缺乏症最为常见,且与临床分期、免疫分类、营养状况和接受抗逆转录病毒治疗无关。因此,在开始抗逆转录病毒治疗时需要补充锌。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Micronutrients status among human immunodeficiency virus-infected children in Southern India
Introduction: Deficiencies of micronutrients play a role in human immunodeficiency virus (HIV) infection and its severity. Identifying the micronutrient status would guide supplementation, thus al-tering the disease progression and severity. Material and methods: A cross-sectional hospital-based study was conducted in Southern India on hundred HIV-infected children. Estimation of serum micronutrient levels (zinc, copper, and iron) and comparison of the deficient micronutrients with clinical stages, immunological categories, CD4 counts, and nutritional status was performed. Results: Among 100 HIV-infected children, zinc deficiency was the most common (62%), whereas copper and iron deficiency was present in 2% and 1%, respectively. Mean age of children was 11.20 ± 3.14 years, 52% were girls, 24% were malnourished, 76% were receiving antiretroviral therapy (ART), and four had CD4 counts < 200/mm 2 indicating AIDS. Using Kruskalwallis test, serum iron levels ( p = 0.000) and CD4 levels ( p = 0.001) were significantly associated with clinical stages, while serum zinc levels ( p = 0.043) and CD4 levels ( p = 0.000) were significantly associated with various degrees of immune classification. Mean micronutrient levels did not correlate significantly with CD4 counts less than and greater than 350 by unpaired t test. Zinc deficiency did not correlate with clinical staging, immunological classification, nutritional status, and receipt of ART on multiple logistic regression analysis. Conclusion: In HIV-infected children, zinc deficiency was the most common and it did not correlate with clinical staging, immunological classification, nutritional status, and receipt of antiretroviral therapy. Hence, supplementation of zinc would be required along with initiation of ART.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
HIV & AIDS Review
HIV & AIDS Review INFECTIOUS DISEASES-
CiteScore
0.50
自引率
0.00%
发文量
30
审稿时长
12 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信