基于4-(2-羟基苯基)-2-甲基嘧啶的Ag(I)配合物的合成、表征、热行为和抗肿瘤活性

Journal of Chemical Research-s Pub Date : 2022-03-01 DOI:10.1177/17475198221103541

Wu-Wu Li, M. Zheng, Yonghui Shang, Jingwen Xu, Zun-ting Zhang, Hao-Nan Zheng, Xiao-Peng Li, A-Tong Weng, Ling-Ying Feng, Luo-sheng Liu

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引用次数: 0

摘要

成功合成了一种新的Ag(I)配合物Ag(C11H10N2O)2·NO3 (C11H10N2O = 4-(2-羟基苯基)-2-甲基嘧啶)，并通过红外光谱、元素分析和单晶x射线衍射分析对其进行了表征。该配合物具有由氢键、π -π堆叠相互作用、配位相互作用和静电相互作用组成的三维框架。此外，采用Kissinger和Ozawa方法研究了配合物的热稳定性和非等温热分解反应动力学。最后，对该复合物对人肺癌细胞(NCI-H460)、人肝癌细胞(HepG2)和人乳腺癌细胞(MCF7)的抗肿瘤能力进行了评价。该复合物对HepG2和MCF7癌细胞具有有效的抗肿瘤活性。

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Synthesis, characterization, thermal behavior, and antitumor activities of an Ag(I) complex based on 4-(2-hydroxyphenyl)-2-methylpyrimidine

A new Ag(I) coordination complex, Ag(C11H10N2O)2·NO3 (C11H10N2O = 4-(2-hydroxyphenyl)-2-methylpyrimidine) is successfully synthesized and characterized by infrared spectroscopy, elemental analysis, and single-crystal X-ray diffraction analysis. This complex features a three-dimensional framework consisting of hydrogen bonds, π–π stacking interactions, coordination interactions, and electrostatic interactions. Moreover, the thermal stability and non-isothermal thermal decomposition reaction kinetics of the complex are well investigated by the methods of Kissinger and Ozawa. Finally, the antitumor ability of the complex is evaluated against human lung cancer cells (NCI-H460), human hepatocellular cancer cells (HepG2), and human breast cancer cells (MCF7). The complex exhibits potent antitumor activities against HepG2 and MCF7 cancer cells.

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来源期刊

Journal of Chemical Research-s 化学科学, 有机化学, 有机合成

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： The Journal of Chemical Research is a peer reviewed journal that publishes full-length review and research papers in all branches of experimental chemistry. The journal fills a niche by also publishing short papers, a format which favours particular types of work, e.g. the scope of new reagents or methodology, and the elucidation of the structure of novel compounds. Though welcome, short papers should not result in fragmentation of publication, they should describe a completed piece of work. The Journal is not intended as a vehicle for preliminary publications. The work must meet all the normal criteria for acceptance as regards scientific standards. Papers that contain extensive biological results or material relating to other areas of science may be diverted to more appropriate specialist journals. Areas of coverage include: Organic Chemistry; Inorganic Chemistry; Materials Chemistry; Crystallography; Computational Chemistry.