青霉素和抗生素革命的全球历史

R. Haider
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引用次数: 0

摘要

亚历山大·弗莱明(Alexander Fleming)因发现青霉素而被列入20世纪最重要的100人之一。弗莱明将霉菌中的活性成分命名为青霉素,结果证明它是一种具有巨大效力的抗感染剂。“科学上的革命性发展是科学家对某种思想或信仰的看法发生了变化。亚历山大·弗莱明1928年发现青霉素是科学领域的一个革命性发展。这一发现彻底改变了感染的治疗方式,并影响了科学领域、医学领域、制药行业和全人类。亚历山大·弗莱明发现青霉素,引发了抗生素的发展,自革命以来,抗生素一直在拯救人们的生命,使他成为一个革命性的人物。尽管弗莱明不仅对革命性的发展负有单独的责任,但他发现青霉素也导致了抗生素的发展。1945年10月,亚历山大·弗莱明、霍华德·弗洛里和欧内斯特·钱恩分别收到一封来自瑞典斯德哥尔摩的几乎一模一样的电报。这些信息中写道,诺贝尔奖委员会很高兴地通知这三位英国科学家,他们因发现青霉素及其对多种疾病的治疗作用而被授予诺贝尔医学奖。事实上,早在一年前,两家主要报纸就通知读者弗莱明将在1942年获得这一著名奖项。尽管记者们的报道比他们的时代早了一年,但他们是对的,全球科学界普遍认为,世界上第一批抗生素是医学史上值得获得诺贝尔奖的一个里程碑。虽然诺贝尔奖委员会将诺贝尔奖授予研发出青霉素的科学家的决定没有争议,但确切的获奖者选择却更令人担忧。由于药物开发过程漫长而复杂,因此产生了不确定性。故事始于1928年,当时在伦敦圣玛丽医院医学院工作的苏格兰细菌学家亚历山大·弗莱明(Alexander Fleming)注意到一种特殊的霉菌——青霉菌(Penicillium notatum)能抑制细菌的生长,于是他开始更多地了解这种霉菌的不同寻常的特性,弗莱明进行了更多的实验,得出结论,他从霉菌中提取的抗生素溶液变成了一种可用的药物,他确信对这种物质的进一步研究不会有成果。弗莱明转向其他事情。1938年,两位在牛津大学威廉·邓恩爵士病理学院工作的科学家,在接下来的十年里,弗莱明的发现几乎没有引起关注。澳大利亚病理学家霍华德·弗洛里和德国生物化学家欧内斯特·钱恩开始研究抗菌化合物的选择。在接下来的两年里,钱恩、弗洛里和他们的牛津同事对青霉菌进行了实验。在此期间,科学家们取得了几项重要发现,挫败了弗莱明。1940年春天,弗洛里和钱恩研制出了一种药物,他们进行了实验。第二年,他们在牛津进行了第一次初步临床试验。第二次世界大战后,信用之战也获得了重要的民族色彩。在讲述青霉素的发展故事时,记者和政治家们将这种药物纳入了关于国家创造力、创新和个性的庆祝叙事中。在英国和美国的企业创造力神话中,错失的经济机会和被盗的发现将影响随后的抗生素开发和全球药品生产。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Penicillin and the Antibiotics Revolution Global History
Alexander Fleming was one of the 100 most important people of the 20th century for his discovery of Penicillin '' It was the discovery that would change the course of history. The active ingredient in the mold, which Fleming named penicillin, turned out to be an infection-fighting agent of enormous potency'' A revolutionary development in science is a change in the way scientists perceive a certain idea or belief. The finding of Penicillin by Alexander Fleming in 1928 was a revolutionary development in the field of science. The discovery revolutionized the way infections were treated as well as impacted the scientific field, the medical field, the pharmaceuticals industry, and all humanity. Alexander Fleming's discovery of Penicillin sparked the development of antibiotics, which has continued to save People's lives since the revolution, making him a revolutionary figure. Despite the fact that Fleming was not only solely responsible for the revolutionary development, it was also his discovery of Penicillin that led to the development of antibiotics. In October 1945 Alexander Fleming, Howard Florey, and Ernest Chain each received an almost identical telegram from Stockholm, Sweden. The Nobel prize committee, these messages read, was pleased to inform the three British - based scientists that they had been awarded the Nobel prize for Medicine, for the discovery of Penicillin and its curative action in various disease1. This was not surprising news, In Fact, a year earlier, two major newspapers had informed their readers that Fleming would receive the prestigious award in 19442. Although reporters' stories were a year a hand of their time, they were right that the global scientific community had generally agreed that the world's first antibiotics were a landmark in medical history worthy of Nobel prize recognition. While the committee's decision to award the Nobel prize to the scientists who had developed penicillin was not controversial, the precise choice of whom to award the prize to was more fraught. The uncertainty arose because of the long and complicated process of drug development. The story began in 1928 when Alexander Fleming a Scottish bacteriologist working at St. Mary's Hospital Medical school in London, noticed that a specific strain of mold, Penicillium notatum, inhibited the growth of bacteria setting out to understand more about the mold s unusual properties, Fleming conducted additional experiments concluded that the antibiotics solution that he had made from the mold into a useable drug, convinced that further research on the substance would not be fruitful, Fleming turned to other matters. For a decade, Fleming's discovery attracted little attention then in 1938, two scientists working at the University of Oxford's Sir William Dunn School of Pathology. Howard Flory, an Australian Pathologist, and Ernest Chain, a German biochemist began researching a selection of antibacterial compounds. Over the next two years, chain and Florey, and their oxford colleagues experimented on Penicillium notatum. During that time, the scientists made several important discoveries and thwarted Fleming. By the spring of 1940, Florey and chain had developed a drug, which they mice. The following year, they carried out the first preliminary clinical trials on oxford. After the second world war, the battle for credit also acquired important national overtones. In telling the story of Penicillin's development, journalists and politicians incorporated the drug into celebratory narratives about national inventiveness, innovation, and character. In Britain and the united states' particularly myths of corporate ingenuity, economic opportunities missed and discoveries stolen would shape subsequent antibiotics development and the global production of Pharmaceuticals.
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