Matthew Ryan Smith, Karan Uppal, Douglas I Walker, Mark J Utell, Philip K Hopke, Timothy M Mallon, Pamela L Krahl, Patricia Rohrbeck, Young-Mi Go, Dean P Jones
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Environmental Chemicals Altered in Association With Deployment for High Risk Areas.
Objective: A study was conducted using serum samples and high-resolution metabolomics (HRM) to test for changes in abundance of environmental chemicals in deployment in high-risk areas (Balad, Iraq; Bagram, Afghanistan).
Methods: Pre and Post-deployment serum samples for deployment (cases) and matched controls stationed domestically were analyzed by HRM and bioinformatics for the relative abundance of 271 environmental chemicals.
Results: Of the 271 chemicals, 153 were measurable in at least 80% of the samples in one of the pre- or post-deployment groups. Several pesticides and other chemicals were modestly elevated post-deployment in the Control as well as the Bagram and Balad samples. Similarly, small decreases were seen for some chemicals.
Conclusion: These results using serum samples show that for the 271 environmental chemicals studied, 56% were detected and small differences occurred with deployment to high-risk areas.
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