慢性阻塞性肺疾病患者因COVID-19住院后持续呼吸衰竭和再入院

IF 2.7 3区 医学 Q2 RESPIRATORY SYSTEM
Juan Marco Figueira-Gonçalves, Miguel Ángel García-Bello, Yolanda Ramallo-Fariña, Raúl Méndez, Ana Latorre Campos, Paula González-Jiménez, Germán Peces-Barba, María Molina-Molina, Pedro Pablo España, Estela García, Santiago de Jorge Domínguez-Pazos, Marta García Clemente, Carolina Panadero, David de la Rosa-Carrillo, Oriol Sibila, María Dolores Martínez-Pitarch, Nuria Toledo-Pons, Cecilia López-Ramirez, Wanda Almonte-Batista, Abigail Macías-Paredes, Diana Badenes-Bonet, Eli Nancy Pérez-Rodas, Javier Lázaro, Sarai Quirós Fernández, Rosa Cordovilla, Irene Cano-Pumarega, Antoni Torres, Rosario Menendez
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引用次数: 0

摘要

背景:慢性阻塞性肺疾病(COPD)与因SARS-CoV2 (COVID-19)住院期间较差的临床进展/生存相关。本研究的目的是了解这些患者在出院时的情况以及在接下来的12个月内再入院/死亡的风险。方法:我们对RECOVID注册表进行了亚分析。一项多中心观察性研究,回顾性收集了COVID-19严重急性发作的数据,并对幸存者进行了长达一年的随访。数据收集方案包括一般人口统计数据、吸烟、合并症、药物治疗、感染严重程度、住院期间并发症和所需治疗。出院时记录静息血氧饱和度(SpO2)、mMRC(改良医学研究委员会)评定的呼吸困难及长期氧疗处方。随访数据库包括6个月和12个月的临床管理访问,记录再入院和死亡率。结果:共纳入2047例患者(5.6%诊断为COPD)。出院时,COPD患者有更大的呼吸困难,更需要处方家庭氧气。在调整年龄、性别和Charlson合病指数后,COPD患者因呼吸系统原因再次住院的风险更高(HR 2.57 [1.35-4.89], p = 0.004),但生存率无显著差异。结论:克服严重SARS-CoV2感染的COPD患者出院时临床情况较差,因呼吸道原因再次住院的风险较大。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Persistent Respiratory Failure and Re-Admission in Patients with Chronic Obstructive Pulmonary Disease Following Hospitalization for COVID-19.

Background: Chronic obstructive pulmonary disease (COPD) has been associated with worse clinical evolution/survival during a hospitalization for SARS-CoV2 (COVID-19). The objective of this study was to learn the situation of these patients at discharge as well as the risk of re-admission/mortality in the following 12 months.

Methods: We carried out a subanalysis of the RECOVID registry. A multicenter, observational study that retrospectively collected data on severe acute COVID-19 episodes and follow-up visits for up to a year in survivors. The data collection protocol includes general demographic data, smoking, comorbidities, pharmacological treatment, infection severity, complications during hospitalization and required treatment. At discharge, resting oxygen saturation (SpO2), dyspnea according to the mMRC (modified Medical Research Council) scale and long-term oxygen therapy prescription were recorded. The follow-up database included the clinical management visits at 6 and 12 months, where re-admission and mortality were recorded.

Results: A total of 2047 patients were included (5.6% had a COPD diagnosis). At discharge, patients with COPD had greater dyspnea and a greater need for prescription home oxygen. After adjusting for age, sex and Charlson comorbidity index, patients with COPD had a greater risk of hospital re-admission due to respiratory causes (HR 2.57 [1.35-4.89], p = 0.004), with no significant differences in survival.

Conclusion: Patients with COPD who overcome a serious SARS-CoV2 infection show a worse clinical situation at discharge and a greater risk of re-admission for respiratory causes.

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来源期刊
CiteScore
4.80
自引率
10.70%
发文量
372
审稿时长
16 weeks
期刊介绍: An international, peer-reviewed journal of therapeutics and pharmacology focusing on concise rapid reporting of clinical studies and reviews in COPD. Special focus will be given to the pathophysiological processes underlying the disease, intervention programs, patient focused education, and self management protocols. This journal is directed at specialists and healthcare professionals
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