pnpla介导的脂质水解和转酰基化-在分解代谢和合成代谢的交叉点。

IF 3.9 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochimica et biophysica acta. Molecular and cell biology of lipids Pub Date : 2023-11-09 DOI:10.1016/j.bbalip.2023.159410

Mariana Colaço-Gaspar , Peter Hofer , Monika Oberer , Rudolf Zechner

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引用次数: 0

摘要

Patatin-like phospholipase domain containing protein (PNPLAs)在脂质代谢中发挥着多种作用。在这篇综述中，我们重点研究了PNPLA1-5的酶学性质和预测的三维结构，PNPLA2-4同时发挥分解代谢和合成代谢功能。PNPLA1主要表达于表皮并参与鞘脂的生物合成，而PNPLA2和4则普遍表达并表现出多种酶活性，包括水解和转酰基化各种(甘油-)脂类。本文综述了已知的pnpla介导的水解和转酰基化反应的生物学作用，并强调了其生理功能的开放性问题。

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PNPLA-mediated lipid hydrolysis and transacylation – At the intersection of catabolism and anabolism

Patatin-like phospholipase domain containing proteins (PNPLAs) play diverse roles in lipid metabolism. In this review, we focus on the enzymatic properties and predicted 3D structures of PNPLA1-5. PNPLA2-4 exert both catabolic and anabolic functions. Whereas PNPLA1 is predominantly expressed in the epidermis and involved in sphingolipid biosynthesis, PNPLA2 and 4 are ubiquitously expressed and exhibit several enzymatic activities, including hydrolysis and transacylation of various (glycero-)lipid species. This review summarizes known biological roles for PNPLA-mediated hydrolysis and transacylation reactions and highlights open questions concerning their physiological function.

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来源期刊

Biochimica et biophysica acta. Molecular and cell biology of lipids 生物-生化与分子生物学

CiteScore

11.00

自引率

2.10%

发文量

109

审稿时长

53 days

期刊介绍： BBA Molecular and Cell Biology of Lipids publishes papers on original research dealing with novel aspects of molecular genetics related to the lipidome, the biosynthesis of lipids, the role of lipids in cells and whole organisms, the regulation of lipid metabolism and function, and lipidomics in all organisms. Manuscripts should significantly advance the understanding of the molecular mechanisms underlying biological processes in which lipids are involved. Papers detailing novel methodology must report significant biochemical, molecular, or functional insight in the area of lipids.