罗伊氏乳杆菌对光疗新生儿高胆红素血症患者血清胆红素水平的影响

IF 0.2 Q4 PEDIATRICS
Deska Andina Rezki, I. Firmansyah, Dora Darussalam, Sulaiman Yusuf, Nora Sovira, Bakhtiar Bakhtiar
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引用次数: 0

摘要

背景:高胆红素血症发生在60%的足月婴儿和80%的早产儿中。光疗是主要的治疗方法,但它有副作用,有时需要住院治疗,并导致婴儿与母亲分离。不发达的肠道菌群和增加的肠肝循环新生儿有助于提高血清胆红素水平在生命早期。目的观察添加益生菌罗伊氏乳杆菌对高胆红素血症足月新生儿光疗的疗效。方法在这项双盲随机临床试验中,将印度尼西亚班达亚齐Zainoel Abidin医生医院的高胆红素血症足月婴儿随机分为干预组和对照组。所有受试者均接受光疗。在光疗开始前,干预组每天口服5滴罗伊氏乳杆菌,而对照组则服用安慰剂。观察两组患者24小时光疗后的胆红素水平。结果42例足月新生儿符合纳入标准。干预组血清总胆红素(TSB)水平(6517 mg/dL)明显低于对照组(4434 mg/dL) (P<0.001),光照24小时后,干预组间接胆红素水平下降6.40 mg/dL,对照组下降4.43 mg/dL (P<0.001)。结论在接受24小时光疗的高胆红素血症足月新生儿中,与对照组相比,添加益生菌罗伊氏乳杆菌可显著降低总胆红素和间接胆红素水平。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The effectiveness of Lactobacillus reuteri on serum bilirubin levels in neonatal hyperbilirubinemia with phototherapy
Background Hyperbilirubinemia occurs in 60% of full term and 80% of premature infants. Phototherapy is the main treatment, but it has side effects, sometimes requires hospitalization, and causes the baby to be separated from the mother. Underdeveloped gut microflora and increased enterohepatic circulation in newborns contribute to increased serum bilirubin levels in early life. Objective To assess the efficacy of adding probiotic L. reuteri on phototherapy in full-term neonates with hyperbilirubinemia. Methods In this double-blind, randomized clinical trial, full term infants with hyperbilirubinemia at Dr. Zainoel Abidin Hospital, Banda Aceh, Aceh, Indonesia, were randomly assigned to either an intervention or control group. All subjects received phototherapy. The intervention group was also given five drops of L. reuteri once a day orally before phototherapy started, while the control group received a placebo. Bilirubin levels after 24-hour phototherapy were evaluated in both groups. Results A total of 42 term neonates met the inclusion criteria. The intervention group had a significantly greater decrease in total serum bilirubin (TSB) level (6,517 mg/dL) than did the control group (4,434 mg/dL) (P<0.001), as well in indirect bilirubin levels in the intervention group had decrease 6.40 mg/dL while in the control group 4.43 mg/dL after 24 hours of phototherapy (P<0.001). Conclusion In full-term neonates with hyperbilirubinemia who underwent 24-hour phototherapy, adding probiotic L. reuteri leads to a significantly greater reduction in total and indirect bilirubin levels compared to the control group.
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来源期刊
CiteScore
0.40
自引率
0.00%
发文量
58
审稿时长
24 weeks
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