Indah Septiane, F. Kadi, T. Yuniati, Nina Surtiretna, Aris Primadi
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引用次数: 0
摘要
背景:早发性新生儿脓毒症是危及早产儿生命的潜在问题。诊断早发新生儿败血症具有挑战性。诊断困难可能会延误最终治疗。目的分析28-36周胎龄新生儿早发型脓毒症(EONS)风险与平均血小板体积(MPV)及未成熟血小板分数(IPF)的潜在关系。方法在西爪哇万隆的Dr. Hasan Sadikin总医院进行前瞻性队列研究。平均血小板体积(MPV)和IPF在出生后的前6小时和第一次检查后的48-72小时进行评估。检查后观察脓毒症的发展。采用双逻辑回归分析。结果115例早产儿中,45例(39.1%)发生早发型新生儿脓毒症。平均MPV和平均IPF的升高差异有统计学意义(P<0.05)。双逻辑回归分析显示,平均MPV增加(ORadj=6.14;95%CI 1.99 ~ 18.96;P=0.002)和平均IPF (ORadj=6.56;95%CI 2.64 ~ 16.34;P<0.001)与脓毒症风险增加显著相关。结论MPV和IPF升高与早产儿EONS发生率增高有关。
Mean platelet volume and immature platelet fraction as predictors of early onset neonatal sepsis risk in neonates of 28-36 weeks gestational age
Background Early onset neonatal sepsis is a potential life-threatening problem for preterm infant. Diagnosing early onset neonatal sepsis is challenging. Difficulties in establishing diagnosis might cause delay definitive treatment.
Objective To analyze for potential associations between early onset neonatal sepsis (EONS) risk and mean platelet volume (MPV) as well as immature platelet fraction (IPF) in neonates of 28-36 weeks gestational age.
Methods A prospective cohort study was conducted at Dr. Hasan Sadikin General Hospital, Bandung, West Java. Mean platelet volume (MPV) and IPF were evaluated in the first ?6 hours of life and during the 48-72 hours after the first examination. This examination was followed by observation for sepsis development. Double logistic regression analysis was used.
Results Of 115 subjects, 45 preterm infants (39.1%) developed early onset neonatal sepsis. The increase in both mean MPV and mean IPF were significantly different (P<0.05). Double logistic regression analysis revealed that an increase in mean MPV (ORadj=6.14; 95%CI 1.99 to 18.96; P=0.002) and mean IPF (ORadj=6.56; 95%CI 2.64 to 16.34; P<0.001) were significantly associated with increased risk of sepsis.
Conclusion The MPV and IPF increase are associated with greater incidence of EONS in preterm infants.