激光辅助给药维生素C, E和阿魏酸血清消融后的安全性:回顾性图表回顾

IF 1.2 4区 医学 Q3 DERMATOLOGY
H. Johnson, Tiana Kazemi, R. Farah
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引用次数: 3

摘要

【摘要】目的:据报道,局部应用复合维生素C、维生素E和阿魏酸血清,可缩短术后停机时间,改善伤口愈合。然而,经皮药妆的药物输送最初用于局部应用也已被证明有意想不到的副作用。我们研究的目的是报告我们单一学术中心经验的安全性数据,包括在分次烧蚀CO2激光治疗后立即局部应用含有维生素c的药妆治疗的患者,重点是可报告的副作用。方法:对2015年1月1日至2018年12月31日在明尼苏达大学M健康化妆品中心接受分次CO2消融(10,600 nm)激光手术的所有患者进行回顾性图表回顾,这些患者在任何诊断后立即一次性应用含有15%维生素C、1%维生素E和0.5%阿魏酸的联合血清(C E阿魏酸®,SkinCeuticals Inc., New York, NY)。儿科和研究选择退出的患者被排除在外。对这些患者的医疗记录进行人工审查,包括以下内容:年龄、性别、诊断、地点、术后护理说明、抗病毒和/或抗菌预防药物的使用以及术后副作用的记录。结果:33例患者(共45次治疗)符合纳入标准。有10例预期的副作用:红斑(6例),红斑伴压痛(1例),红斑伴轻度隆起(1例),皮肤脱皮伴图案标记(1例),疼痛伴轻微出血(1例)。这些都归因于正常的术后过程,无并发症解决。局部应用维生素C、维生素E和阿魏酸血清没有副作用的报道。结论:局部应用维生素C,维生素E和阿魏酸血清后立即分次消融CO2激光治疗不会导致相关并发症。然而,这些结果可能不能推广到较长的应用程序,超出直接的术后时间周期,也不能推广到其他药妆配方。需要更多的研究来检查局部药妆血清在激光辅助给药中的安全性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Safety profile of laser-assisted drug delivery of vitamin C, E, and ferulic acid serum following ablative fractional resurfacing: A retrospective chart review
ABSTRACT Objectives: The topical application of a combination Vitamin C, Vitamin E, and Ferulic acid serum following ablative fractional resurfacing has been reported to shorten post-procedure downtime and improve wound healing. However, transcutaneous drug delivery of cosmeceuticals initially meant for topical application have also been shown to have unintended side effects. The objective of our study was to report safety data from our single academic center experience consisting of patients treated with topical application of a vitamin C-containing cosmeceutical immediately following fractional ablative CO2 laser treatment with a focus on reportable side effects. Methods: A retrospective chart review of all patients at the University of Minnesota M Health Cosmetic Center who had fractional ablative CO2 (10,600 nm) laser procedure for any diagnosis followed by immediate one-time application of a combination serum containing 15% Vitamin C, 1% Vitamin E, and 0.5% Ferulic acid (C E Ferulic®, SkinCeuticals Inc., New York, NY) from Jan 1, 2015 to Dec 31, 2018 was performed. Pediatric and research opt-out patients were excluded. The medical records of these patients were manually reviewed for the following: age, sex, diagnosis, location, after-care instructions, antiviral and/or antibacterial prophylaxis use, and documentation of post-procedure side effects. Results: Thirty-three patients, encompassing a total of 45 treatment encounters, met inclusion criteria. There were ten cases of expected side effects: erythema (6), erythema with tenderness (1), erythema with mild bumpiness (1), skin peeling with pattern marking (1), and pain with slight bleeding (1). These were attributed to the normal post-procedure course and resolved without complications. There were no reported side effects related to the topical application of Vitamin C, Vitamin E, and Ferulic acid serum. Conclusions: The topical application of a Vitamin C, Vitamin E, and Ferulic acid serum immediately following fractional ablative CO2 laser therapy did not result in associated complications. However, these results may not be generalizable to longer application courses beyond the immediate post-procedure time period, nor to other cosmeceutical formulations. More studies examining the safety profile of topical cosmeceutical serums in laser-assisted drug delivery are needed.
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来源期刊
CiteScore
2.50
自引率
0.00%
发文量
36
审稿时长
>12 weeks
期刊介绍: A unique journal that focuses on the application of cosmetic laser and light therapies on the skin. The Journal of Cosmetic & Laser Therapy provides a forum for stimulating and up-to-date studies demonstrating the wide range of therapeutic options for clinicians and surgeons involved in cosmetic and dermatological treatment. The journal is aimed at dermatologists, cosmetic surgeons, plastic and facial plastic surgeons, oculoplastic surgeons and all those interested in the rapidly expanding field of cosmetic and laser therapy. Features include: -Cosmetic surgery, including facial rejuvenation, hair removal and skin resurfacing -Use of lasers and other light sources for cosmetic and dermatological treatment -Applications of peeling agents, fillers, injectables, implants and other cosmetic modalities -Topical treatments -Practical tips and safety issues
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