无创产前筛查在俄罗斯唐氏综合征检测中的应用经验:一项回顾性队列研究

IF 0.8 Q4 REPRODUCTIVE BIOLOGY
E. V. Kudryavtseva, V. Kovalev, I. Baranov, A. A. Dektyarev
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引用次数: 0

摘要

目的:评估无创产前筛查(NIPS)在识别唐氏综合征高危孕妇中的有效性。材料与方法:回顾性队列研究纳入2013年1月至2018年12月在俄罗斯接受NIPS的25798名孕妇。21042名和4756名参与者分别接受了美国Natera实验室(无创产前检测1,npt -1)和俄罗斯Genomed实验室(无创产前检测2,npt -2)的检测。结果:21三体(T21)高危患者544例(2.59%)。T21高危妇女的平均年龄为37.3岁。根据NIPT结果,T21低风险患者的平均年龄为33.8岁(P<0.001)。535例行有创产前诊断。在7例(1.3%)病例中,胎儿中存在T21未被证实。528例(97.3%)胎儿核型确诊T21。T21低风险女性(N = 25086)中,有4例(0.015%)遗漏了胎儿21三体。因此,俄罗斯NIPS与T21相关的有效性指标如下:敏感性- 99.25%,特异性- 99.96%,PPV - 98.7%, NPV - 99.98%。在妊娠早期,在胎儿T21存在的情况下,胎儿游离dna分数水平明显降低。结论:NIPS在妊娠管理方案中具有良好的应用前景,可提高产前T21检测的有效性。胎儿分数的水平与胎儿T21的存在有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Experience in the Application of Non-invasive Prenatal Screening for the Detection of Down Syndrome in Russia: A Retrospective Cohort Study
Objectives: Assessment the effectiveness of non-invasive prenatal screening (NIPS) for identifying pregnant women at high risk of giving birth to a child with Down syndrome. Materials and Methods: The retrospective cohort study included 25798 pregnant women who underwent NIPS in Russia from January 2013 to December 2018. 21042 and 4756 participants underwent tests from the Natera laboratory, USA (non-invasive prenatal test 1, NIPT-1) and the Genomed laboratory, Russia (non-invasive prenatal test 2, NIPT-2), respectively. Results: A high risk of trisomy 21 (T21) was detected in 544 cases (2.59%). The mean age in women at high risk of T21 was 37.3 years. According to the NIPT results, in patients who revealed a low risk of T21, the mean age was 33.8 years (P<0.001). In 535 cases, invasive prenatal diagnosis was performed. In 7 (1.3%) cases, the presence of T21 in the fetus was not confirmed. In 528 (97.3%) cases, T21 was confirmed by fetal karyotyping. Among women who revealed a low risk of T21 (N = 25086), in 4 cases (0.015%), fetal trisomy 21 was missed. Thus, the indicators of the effectiveness of NIPS in Russia in relation to T21 are as follows: sensitivity - 99.25%, specificity - 99.96%, PPV - 98.7%, NPV - 99.98%. In the first trimester, in the presence of fetal T21, the level of the fetal fraction of free-DNA is significantly lower. Conclusions: NIPS has good prospects for implementation in pregnancy management programs and increasing the effectiveness of prenatal detection of T21. The level of the fetal fraction is associated with the presence of fetal T21.
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来源期刊
CiteScore
1.60
自引率
14.30%
发文量
8
期刊介绍: All kind of knowledge contributing to the development of science by its content, value, level and originality will be covered by IJWHR. Problems of public health and their solutions are at the head of the windows opening us to the world. The "International Journal of Women''s Health and Reproduction Sciences” is a modern forum for scientific communication, covering all aspects women health and reproduction sciences, in basic and clinical sciences, mainly including: -Medical Education in Women Health and Reproduction Sciences -Cardiology in Women Health-Related Reproductive Problems -Sports Medicine in Women Health and Reproduction Sciences -Psychiatry in Women Health-Related Reproductive Problems -Antioxidant Therapy in Reproduction Medicine Sciences -Nutrition in Women Health and Reproduction Sciences -Defense Androgen and Estrogen -Fertility and Infertility -Urogynecology -Endometriosis -Endocrinology -Breast Cancer -Menopause -Puberty -Eroticism -Pregnancy -Preterm Birth -Vaginal Diseases -Sex-Based Biology -Surgical Procedures -Nursing in Pregnancy -Obstetrics/Gynecology -Polycystic Ovary Syndrome -Hyperandrogenism in Females -Menstrual Syndrome and Complications -Oncology of Female Reproductive Organs -Traditional Medicine in Women Reproductive Health -Ultrasound in Women Health Reproduction sciences -Stem Cell Research In Women Reproduction Sciences -Complementary Medicine in Women Reproductive Health -Female Sexual Dysfunction: Pathophysiology & Treatment
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