破坏表皮通透性屏障增强紫外线诱导的色素沉着

Photodermatology Pub Date : 2020-03-01 DOI:10.1111/phpp.12515

Yan Li, Chun-Yan Yang, M. Man, Hua Gu, Wenjuan Wu, Ying Tu, Dong-Mei Ding, Li He

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引用次数: 3

摘要

表皮渗透性屏障不仅可以防止经皮水分和营养物质的流失，还可以保护身体免受外界的侵害(1,2)。先前的研究表明，渗透性屏障功能障碍有利于金黄色葡萄球菌的皮肤定植(3)。此外，表皮渗透性屏障的破坏会增加局部物质的经皮吸收(4)。有缺陷的表皮通透性屏障也降低了红斑对UVB辐射的阈值。

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Disruption of epidermal permeability barrier enhances UV‐induced hyperpigmentation

The epidermal permeability barrier not only prevents transcutaneous loss of water and nutrients, but also protects the body from the outside insults (1, 2). Prior studies have demonstrated that permeability barrier dysfunction favors cutaneous colonization of Staphylococcus aureus (3). Moreover, disruption of epidermal permeability barrier increases transcutaneous absorption of topical substances (4). Likewise, a defective epidermal permeability barrier also decreases erythema threshold to UVB radiation.

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Photodermatology

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