{"title":"ru486对妊娠中期大鼠肌层电活动、性类固醇和前列腺素F2α浓度的影响","authors":"Bouchra Bouftila, Monique Clabaut","doi":"10.1016/S0764-4469(01)01358-0","DOIUrl":null,"url":null,"abstract":"<div><p>Effects of RU 486 (10 mg·kg<sup>–1</sup>, per.os) were assessed at mid-pregnancy in the rat. One hour after RU 486 treatment, myometrial electrical activity stayed low. It increased from the 3rd hour after administration of RU 486 and a perfect synchronization of the bursts of the action potentials was observed from the 6th h to the 24th h. Tissular steroid hormones and PGF<sub>2α</sub>, evaluated at hour 6 after RU 486 administration, showed a decrease of progesterone concentrations in both myometrium and uterus. Estradiol levels decreased in uterus whereas, PGF<sub>2α</sub> levels increased in both myometrium and uterus. These results show for the first time that RU 486 strongly increases the myometrial electrical activity in the rat at mid-pregnancy. This action was closely related to E<sub>2</sub>, P<sub>4</sub> and PGF<sub>2α</sub> concentrations.</p></div>","PeriodicalId":100306,"journal":{"name":"Comptes Rendus de l'Académie des Sciences - Series III - Sciences de la Vie","volume":"324 9","pages":"Pages 805-813"},"PeriodicalIF":0.0000,"publicationDate":"2001-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0764-4469(01)01358-0","citationCount":"0","resultStr":"{\"title\":\"Effects of RU 486 on electrical activity, on sexual steroid and prostaglandin F2α concentrations in the myometrium at mid-pregnancy in the rat\",\"authors\":\"Bouchra Bouftila, Monique Clabaut\",\"doi\":\"10.1016/S0764-4469(01)01358-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Effects of RU 486 (10 mg·kg<sup>–1</sup>, per.os) were assessed at mid-pregnancy in the rat. One hour after RU 486 treatment, myometrial electrical activity stayed low. It increased from the 3rd hour after administration of RU 486 and a perfect synchronization of the bursts of the action potentials was observed from the 6th h to the 24th h. Tissular steroid hormones and PGF<sub>2α</sub>, evaluated at hour 6 after RU 486 administration, showed a decrease of progesterone concentrations in both myometrium and uterus. Estradiol levels decreased in uterus whereas, PGF<sub>2α</sub> levels increased in both myometrium and uterus. These results show for the first time that RU 486 strongly increases the myometrial electrical activity in the rat at mid-pregnancy. This action was closely related to E<sub>2</sub>, P<sub>4</sub> and PGF<sub>2α</sub> concentrations.</p></div>\",\"PeriodicalId\":100306,\"journal\":{\"name\":\"Comptes Rendus de l'Académie des Sciences - Series III - Sciences de la Vie\",\"volume\":\"324 9\",\"pages\":\"Pages 805-813\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2001-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0764-4469(01)01358-0\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Comptes Rendus de l'Académie des Sciences - Series III - Sciences de la Vie\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0764446901013580\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Comptes Rendus de l'Académie des Sciences - Series III - Sciences de la Vie","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0764446901013580","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effects of RU 486 on electrical activity, on sexual steroid and prostaglandin F2α concentrations in the myometrium at mid-pregnancy in the rat
Effects of RU 486 (10 mg·kg–1, per.os) were assessed at mid-pregnancy in the rat. One hour after RU 486 treatment, myometrial electrical activity stayed low. It increased from the 3rd hour after administration of RU 486 and a perfect synchronization of the bursts of the action potentials was observed from the 6th h to the 24th h. Tissular steroid hormones and PGF2α, evaluated at hour 6 after RU 486 administration, showed a decrease of progesterone concentrations in both myometrium and uterus. Estradiol levels decreased in uterus whereas, PGF2α levels increased in both myometrium and uterus. These results show for the first time that RU 486 strongly increases the myometrial electrical activity in the rat at mid-pregnancy. This action was closely related to E2, P4 and PGF2α concentrations.
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