Jiesuck Park, Hack‐Lyoung Kim, Myung-A Kim, Mi-Na Kim, S. Park, H. Yoon, M. Shin, K. Hong, W. Shim
{"title":"稳定性胸痛患者的传统心血管危险因素与阻塞性冠状动脉疾病:性别分析","authors":"Jiesuck Park, Hack‐Lyoung Kim, Myung-A Kim, Mi-Na Kim, S. Park, H. Yoon, M. Shin, K. Hong, W. Shim","doi":"10.51789/CMSJ.2021.1.E7","DOIUrl":null,"url":null,"abstract":"Background and Objectives: The effect of gender difference on the association between major cardiovascular risk factors and obstructive coronary artery disease (CAD) has not yet been fully determined. We investigated whether the strength of association between traditional cardiovascular risk factors and obstructive CAD differs according to gender in patients with stable chest pain. Methods: A total of 1,254 patients (61.0±11.2 years, 45.7% women) with stable chest pain who had elective invasive coronary angiography under suspicion of obstructive CAD were reviewed from the KoRean wOmen'S chest pain rEgistry multi-center registry database. Obstructive CAD was defined as ≥50% diameter stenosis in ≥1 epicardial coronary arteries. Age, body mass index, hypertension, diabetes mellitus, dyslipidemia, and smoking were focused as traditional risk factors. Results: Of the total patients, 453 (36.1%) had obstructive CAD (men vs. women: 38.0 vs. 33.9%, p=0.140). In multivariable analyses, old age (≥65 years) (odds ratio [OR], 1.92; 95% confidence interval [CI], 1.37–2.69; p<0.001) was only associated to obstructive CAD in men. In women, however, old age (OR, 2.02; 95% CI, 1.39–2.94; p=0.002), hypertension (OR, 1.76; 95% CI, 1.19–2.61; p=0.005) and diabetes mellitus (OR, 2.06; 95% CI, 1.30–3.26; p=0.002) were associated to obstructive CAD. The association between multiple risk factors and obstructive CAD was stronger in women compared to men. Conclusions: Among women presenting stable angina, those with old age, hypertension, diabetes mellitus or multiple cardiovascular risk factors need a higher suspicion for obstructive CAD.","PeriodicalId":87477,"journal":{"name":"Journal of the cardiometabolic syndrome","volume":"2 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Traditional Cardiovascular Risk Factors and Obstructive Coronary Disease in Patients with Stable Chest Pain: Gender-specific Analysis\",\"authors\":\"Jiesuck Park, Hack‐Lyoung Kim, Myung-A Kim, Mi-Na Kim, S. Park, H. Yoon, M. Shin, K. Hong, W. Shim\",\"doi\":\"10.51789/CMSJ.2021.1.E7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background and Objectives: The effect of gender difference on the association between major cardiovascular risk factors and obstructive coronary artery disease (CAD) has not yet been fully determined. We investigated whether the strength of association between traditional cardiovascular risk factors and obstructive CAD differs according to gender in patients with stable chest pain. Methods: A total of 1,254 patients (61.0±11.2 years, 45.7% women) with stable chest pain who had elective invasive coronary angiography under suspicion of obstructive CAD were reviewed from the KoRean wOmen'S chest pain rEgistry multi-center registry database. Obstructive CAD was defined as ≥50% diameter stenosis in ≥1 epicardial coronary arteries. Age, body mass index, hypertension, diabetes mellitus, dyslipidemia, and smoking were focused as traditional risk factors. Results: Of the total patients, 453 (36.1%) had obstructive CAD (men vs. women: 38.0 vs. 33.9%, p=0.140). In multivariable analyses, old age (≥65 years) (odds ratio [OR], 1.92; 95% confidence interval [CI], 1.37–2.69; p<0.001) was only associated to obstructive CAD in men. In women, however, old age (OR, 2.02; 95% CI, 1.39–2.94; p=0.002), hypertension (OR, 1.76; 95% CI, 1.19–2.61; p=0.005) and diabetes mellitus (OR, 2.06; 95% CI, 1.30–3.26; p=0.002) were associated to obstructive CAD. The association between multiple risk factors and obstructive CAD was stronger in women compared to men. Conclusions: Among women presenting stable angina, those with old age, hypertension, diabetes mellitus or multiple cardiovascular risk factors need a higher suspicion for obstructive CAD.\",\"PeriodicalId\":87477,\"journal\":{\"name\":\"Journal of the cardiometabolic syndrome\",\"volume\":\"2 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the cardiometabolic syndrome\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.51789/CMSJ.2021.1.E7\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the cardiometabolic syndrome","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.51789/CMSJ.2021.1.E7","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Traditional Cardiovascular Risk Factors and Obstructive Coronary Disease in Patients with Stable Chest Pain: Gender-specific Analysis
Background and Objectives: The effect of gender difference on the association between major cardiovascular risk factors and obstructive coronary artery disease (CAD) has not yet been fully determined. We investigated whether the strength of association between traditional cardiovascular risk factors and obstructive CAD differs according to gender in patients with stable chest pain. Methods: A total of 1,254 patients (61.0±11.2 years, 45.7% women) with stable chest pain who had elective invasive coronary angiography under suspicion of obstructive CAD were reviewed from the KoRean wOmen'S chest pain rEgistry multi-center registry database. Obstructive CAD was defined as ≥50% diameter stenosis in ≥1 epicardial coronary arteries. Age, body mass index, hypertension, diabetes mellitus, dyslipidemia, and smoking were focused as traditional risk factors. Results: Of the total patients, 453 (36.1%) had obstructive CAD (men vs. women: 38.0 vs. 33.9%, p=0.140). In multivariable analyses, old age (≥65 years) (odds ratio [OR], 1.92; 95% confidence interval [CI], 1.37–2.69; p<0.001) was only associated to obstructive CAD in men. In women, however, old age (OR, 2.02; 95% CI, 1.39–2.94; p=0.002), hypertension (OR, 1.76; 95% CI, 1.19–2.61; p=0.005) and diabetes mellitus (OR, 2.06; 95% CI, 1.30–3.26; p=0.002) were associated to obstructive CAD. The association between multiple risk factors and obstructive CAD was stronger in women compared to men. Conclusions: Among women presenting stable angina, those with old age, hypertension, diabetes mellitus or multiple cardiovascular risk factors need a higher suspicion for obstructive CAD.