稳定性胸痛患者的传统心血管危险因素与阻塞性冠状动脉疾病:性别分析

Jiesuck Park, Hack‐Lyoung Kim, Myung-A Kim, Mi-Na Kim, S. Park, H. Yoon, M. Shin, K. Hong, W. Shim
{"title":"稳定性胸痛患者的传统心血管危险因素与阻塞性冠状动脉疾病:性别分析","authors":"Jiesuck Park, Hack‐Lyoung Kim, Myung-A Kim, Mi-Na Kim, S. Park, H. Yoon, M. Shin, K. Hong, W. Shim","doi":"10.51789/CMSJ.2021.1.E7","DOIUrl":null,"url":null,"abstract":"Background and Objectives: The effect of gender difference on the association between major cardiovascular risk factors and obstructive coronary artery disease (CAD) has not yet been fully determined. We investigated whether the strength of association between traditional cardiovascular risk factors and obstructive CAD differs according to gender in patients with stable chest pain. Methods: A total of 1,254 patients (61.0±11.2 years, 45.7% women) with stable chest pain who had elective invasive coronary angiography under suspicion of obstructive CAD were reviewed from the KoRean wOmen'S chest pain rEgistry multi-center registry database. Obstructive CAD was defined as ≥50% diameter stenosis in ≥1 epicardial coronary arteries. Age, body mass index, hypertension, diabetes mellitus, dyslipidemia, and smoking were focused as traditional risk factors. Results: Of the total patients, 453 (36.1%) had obstructive CAD (men vs. women: 38.0 vs. 33.9%, p=0.140). In multivariable analyses, old age (≥65 years) (odds ratio [OR], 1.92; 95% confidence interval [CI], 1.37–2.69; p<0.001) was only associated to obstructive CAD in men. In women, however, old age (OR, 2.02; 95% CI, 1.39–2.94; p=0.002), hypertension (OR, 1.76; 95% CI, 1.19–2.61; p=0.005) and diabetes mellitus (OR, 2.06; 95% CI, 1.30–3.26; p=0.002) were associated to obstructive CAD. The association between multiple risk factors and obstructive CAD was stronger in women compared to men. Conclusions: Among women presenting stable angina, those with old age, hypertension, diabetes mellitus or multiple cardiovascular risk factors need a higher suspicion for obstructive CAD.","PeriodicalId":87477,"journal":{"name":"Journal of the cardiometabolic syndrome","volume":"2 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Traditional Cardiovascular Risk Factors and Obstructive Coronary Disease in Patients with Stable Chest Pain: Gender-specific Analysis\",\"authors\":\"Jiesuck Park, Hack‐Lyoung Kim, Myung-A Kim, Mi-Na Kim, S. Park, H. Yoon, M. Shin, K. Hong, W. Shim\",\"doi\":\"10.51789/CMSJ.2021.1.E7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background and Objectives: The effect of gender difference on the association between major cardiovascular risk factors and obstructive coronary artery disease (CAD) has not yet been fully determined. We investigated whether the strength of association between traditional cardiovascular risk factors and obstructive CAD differs according to gender in patients with stable chest pain. Methods: A total of 1,254 patients (61.0±11.2 years, 45.7% women) with stable chest pain who had elective invasive coronary angiography under suspicion of obstructive CAD were reviewed from the KoRean wOmen'S chest pain rEgistry multi-center registry database. Obstructive CAD was defined as ≥50% diameter stenosis in ≥1 epicardial coronary arteries. Age, body mass index, hypertension, diabetes mellitus, dyslipidemia, and smoking were focused as traditional risk factors. Results: Of the total patients, 453 (36.1%) had obstructive CAD (men vs. women: 38.0 vs. 33.9%, p=0.140). In multivariable analyses, old age (≥65 years) (odds ratio [OR], 1.92; 95% confidence interval [CI], 1.37–2.69; p<0.001) was only associated to obstructive CAD in men. In women, however, old age (OR, 2.02; 95% CI, 1.39–2.94; p=0.002), hypertension (OR, 1.76; 95% CI, 1.19–2.61; p=0.005) and diabetes mellitus (OR, 2.06; 95% CI, 1.30–3.26; p=0.002) were associated to obstructive CAD. The association between multiple risk factors and obstructive CAD was stronger in women compared to men. Conclusions: Among women presenting stable angina, those with old age, hypertension, diabetes mellitus or multiple cardiovascular risk factors need a higher suspicion for obstructive CAD.\",\"PeriodicalId\":87477,\"journal\":{\"name\":\"Journal of the cardiometabolic syndrome\",\"volume\":\"2 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the cardiometabolic syndrome\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.51789/CMSJ.2021.1.E7\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the cardiometabolic syndrome","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.51789/CMSJ.2021.1.E7","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3

摘要

背景和目的:性别差异对主要心血管危险因素与阻塞性冠状动脉疾病(CAD)相关性的影响尚未完全确定。我们调查了在稳定性胸痛患者中,传统心血管危险因素与阻塞性CAD之间的关联强度是否因性别而异。方法:从韩国妇女胸痛登记处的多中心登记数据库中对1254例(61.0±11.2岁,45.7%为女性)有稳定胸痛的患者(45.7%为女性)进行选择性有创冠状动脉造影,怀疑为阻塞性CAD。梗阻性CAD定义为≥1条心外膜冠状动脉直径狭窄≥50%。年龄、体重指数、高血压、糖尿病、血脂异常和吸烟是传统的危险因素。结果:梗阻性CAD患者453例(36.1%)(男∶女∶38.0∶33.9%,p=0.140)。在多变量分析中,老年人(≥65岁)(优势比[OR], 1.92;95%置信区间[CI], 1.37-2.69;p<0.001)仅与男性阻塞性CAD相关。然而,在女性中,老年(OR, 2.02;95% ci, 1.39-2.94;p=0.002),高血压(OR, 1.76;95% ci, 1.19-2.61;p=0.005)和糖尿病(OR, 2.06;95% ci, 1.30-3.26;p=0.002)与阻塞性CAD相关。多种危险因素与阻塞性CAD之间的关联在女性中强于男性。结论:在表现为稳定型心绞痛的女性中,有老年、高血压、糖尿病或多种心血管危险因素的女性需要对阻塞性冠心病有更高的怀疑。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Traditional Cardiovascular Risk Factors and Obstructive Coronary Disease in Patients with Stable Chest Pain: Gender-specific Analysis
Background and Objectives: The effect of gender difference on the association between major cardiovascular risk factors and obstructive coronary artery disease (CAD) has not yet been fully determined. We investigated whether the strength of association between traditional cardiovascular risk factors and obstructive CAD differs according to gender in patients with stable chest pain. Methods: A total of 1,254 patients (61.0±11.2 years, 45.7% women) with stable chest pain who had elective invasive coronary angiography under suspicion of obstructive CAD were reviewed from the KoRean wOmen'S chest pain rEgistry multi-center registry database. Obstructive CAD was defined as ≥50% diameter stenosis in ≥1 epicardial coronary arteries. Age, body mass index, hypertension, diabetes mellitus, dyslipidemia, and smoking were focused as traditional risk factors. Results: Of the total patients, 453 (36.1%) had obstructive CAD (men vs. women: 38.0 vs. 33.9%, p=0.140). In multivariable analyses, old age (≥65 years) (odds ratio [OR], 1.92; 95% confidence interval [CI], 1.37–2.69; p<0.001) was only associated to obstructive CAD in men. In women, however, old age (OR, 2.02; 95% CI, 1.39–2.94; p=0.002), hypertension (OR, 1.76; 95% CI, 1.19–2.61; p=0.005) and diabetes mellitus (OR, 2.06; 95% CI, 1.30–3.26; p=0.002) were associated to obstructive CAD. The association between multiple risk factors and obstructive CAD was stronger in women compared to men. Conclusions: Among women presenting stable angina, those with old age, hypertension, diabetes mellitus or multiple cardiovascular risk factors need a higher suspicion for obstructive CAD.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信