Ying ZHONG , Yuzhuo YOU , Lishan HUANG , Jun FU , Zimin XIAO , Yongyan ZHU , Huaming TAO
{"title":"麻黄酸A，从麻黄根中提取的一种新的酚类化合物","authors":"Ying ZHONG , Yuzhuo YOU , Lishan HUANG , Jun FU , Zimin XIAO , Yongyan ZHU , Huaming TAO","doi":"10.1016/S2707-3688(23)00048-1","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>To study the chemical constituents of the roots of <em>Ephedra sinica</em> Stapf.</p></div><div><h3>Methods</h3><p>The roots of <em>E. sinica</em> were extracted with 90% ethanol and isolated and purified by column chromatography on silica gel, Sephadex LH 20, and semipreparative RP-HPLC. All the compounds were identified based on spectral analysis (including MS, <sup>1</sup>H-NMR and <sup>13</sup>C-NMR, and 2D NMR) and compared with the reported literature. Their cytotoxicities were evaluated against three human cancer cell lines.</p></div><div><h3>Results</h3><p>Two compounds were isolated from the roots of <em>E. sinica</em> and identified as (<em>E</em>)-eicosyl 3,4-dihydroxy-5-methoxycinnamate <strong>(1)</strong> and (<em>E</em>)-hexadecyl-ferulate <strong>(2)</strong>.</p></div><div><h3>Conclusion</h3><p>Compound <strong>1</strong> was a new phenol named ephedrate A, and compound <strong>2</strong> was newly isolated from this plant. These two compounds showed no obvious cytotoxic activity, and their medicinal activities need to be studied further.</p></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"3 3","pages":"Pages 264-267"},"PeriodicalIF":0.0000,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2707368823000481/pdfft?md5=23e157859cc7561df1e576e92b302c1a&pid=1-s2.0-S2707368823000481-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Ephedrate A, a new phenol compound from the root of Ephedra sinica\",\"authors\":\"Ying ZHONG , Yuzhuo YOU , Lishan HUANG , Jun FU , Zimin XIAO , Yongyan ZHU , Huaming TAO\",\"doi\":\"10.1016/S2707-3688(23)00048-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>To study the chemical constituents of the roots of <em>Ephedra sinica</em> Stapf.</p></div><div><h3>Methods</h3><p>The roots of <em>E. sinica</em> were extracted with 90% ethanol and isolated and purified by column chromatography on silica gel, Sephadex LH 20, and semipreparative RP-HPLC. All the compounds were identified based on spectral analysis (including MS, <sup>1</sup>H-NMR and <sup>13</sup>C-NMR, and 2D NMR) and compared with the reported literature. Their cytotoxicities were evaluated against three human cancer cell lines.</p></div><div><h3>Results</h3><p>Two compounds were isolated from the roots of <em>E. sinica</em> and identified as (<em>E</em>)-eicosyl 3,4-dihydroxy-5-methoxycinnamate <strong>(1)</strong> and (<em>E</em>)-hexadecyl-ferulate <strong>(2)</strong>.</p></div><div><h3>Conclusion</h3><p>Compound <strong>1</strong> was a new phenol named ephedrate A, and compound <strong>2</strong> was newly isolated from this plant. These two compounds showed no obvious cytotoxic activity, and their medicinal activities need to be studied further.</p></div>\",\"PeriodicalId\":100787,\"journal\":{\"name\":\"Journal of Holistic Integrative Pharmacy\",\"volume\":\"3 3\",\"pages\":\"Pages 264-267\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2707368823000481/pdfft?md5=23e157859cc7561df1e576e92b302c1a&pid=1-s2.0-S2707368823000481-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Holistic Integrative Pharmacy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2707368823000481\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Holistic Integrative Pharmacy","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2707368823000481","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Ephedrate A, a new phenol compound from the root of Ephedra sinica
Objective
To study the chemical constituents of the roots of Ephedra sinica Stapf.
Methods
The roots of E. sinica were extracted with 90% ethanol and isolated and purified by column chromatography on silica gel, Sephadex LH 20, and semipreparative RP-HPLC. All the compounds were identified based on spectral analysis (including MS, 1H-NMR and 13C-NMR, and 2D NMR) and compared with the reported literature. Their cytotoxicities were evaluated against three human cancer cell lines.
Results
Two compounds were isolated from the roots of E. sinica and identified as (E)-eicosyl 3,4-dihydroxy-5-methoxycinnamate (1) and (E)-hexadecyl-ferulate (2).
Conclusion
Compound 1 was a new phenol named ephedrate A, and compound 2 was newly isolated from this plant. These two compounds showed no obvious cytotoxic activity, and their medicinal activities need to be studied further.
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