环β-二羰基化合物作为11-脱氧前列腺素合成物的一锅法合成

Doklady of the National Academy of Sciences of Belarus Pub Date : 2020-05-17 DOI:10.29235/1561-8323-2020-64-2-186-192

F. S. Pashkovsky, Yu. S. Dontsu, D. I. Korneev, D. B. Rubinov, F. A. Lakhvich

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引用次数: 0

摘要

在环戊烷-1,3-二酮和5-苯四酸的基础上，一锅法合成了11-脱氧前列腺素环β-二羰基合成器。得到的2-烷基(芳基烷基)取代环戊烷-1,3-二酮转化为11-脱氧- pge1和11-脱氧- pge2类似物的环戊酮前体。

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One-pot synthesis of cyclic β-dicarbonyl compounds as synthons for 11-deoxyprostanoids

One-pot synthesis of cyclic β-dicarbonyl synthons for 11-deoxyprostanoids has been developed on the basis of cyclopentane-1,3-dione and 5-phenyl tetronic acid. The obtained 2-alkyl(arylalkyl)-substituted cyclopentane-1,3-diones have been transformed into cyclopentenone precursors of 11-deoxy-PGE 1 and 11-deoxy-PGE 2 analogues.

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Doklady of the National Academy of Sciences of Belarus

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