穿心莲植物化合物作为抗病毒药物治疗COVID-19的计算机潜力:系统综述

Q2 Pharmacology, Toxicology and Pharmaceutics

journal of applied pharmaceutical science Pub Date : 2023-01-01 DOI:10.7324/japs.2023.133107

Shafa Shavira, S. Handayani, Fatmaria Fatmaria

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引用次数: 1

摘要

自2019冠状病毒病(COVID-19)爆发以来，已经进行了许多研究，以开发针对这种病毒性疾病的最终治疗剂。在发现潜在抗病毒化合物的第一步，计算机方法已成为最佳解决方案。据报道，药用植物穿心莲(Andrographis paniculata)中的几种植物化合物具有抑制SARS-CoV-2蛋白的活性。本系统综述旨在确定荆芥化合物对COVID-19的效力。我们在PubMed和Google Scholar两个数据库中进行了系统检索，并纳入了应用计算机方法对COVID-19中的金银花植物化合物进行分析的原创文章。系统评价纳入了29篇原创文章。结果表明，107个金针藤化合物中有50个(46.73%)对SARS-CoV-2具有抑制作用。我们发现SARS-CoV-2的5个蛋白靶点是高度保守的结构，它们是主蛋白酶、木瓜蛋白酶、RNA依赖性RNA聚合酶

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The in-silico potential of Andrographis paniculata phytocompounds as antiviral for the treatment of COVID-19: A systematic review

Since the outbreak of coronavirus disease 2019 (COVID-19), many studies have been conducted to develop definitive therapeutic agents for this viral disease. The in-silico method has become the best solution for the initial step in discovering potential antiviral compounds. Several phytocompounds from a medicinal plant, Andrographis paniculata , were reported to have activity inhibiting SARS-CoV-2 proteins. The present systematic review aims to determine the potency of A. paniculata compounds against COVID-19. We undertook a systematic search in two databases, PubMed and Google Scholar, and included original articles that applied in-silico methods for phytocompounds of A. paniculata in COVID-19. Twenty-nine original articles were included in the systematic review. We report that 50 of the 107 A. paniculata phytocompounds (46.73%) were against SARS-CoV-2. We found that five protein targets of SARS-CoV-2 are highly conserved structures mostly used in the articles, which are main protease, papain-like protease, RNA-dependent RNA polymerase

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来源期刊

journal of applied pharmaceutical science Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

2.20

自引率

0.00%

发文量

224

期刊介绍： Journal of Applied Pharmaceutical Science (JAPS) is a monthly, international, open access, journal dedicated to various disciplines of pharmaceutical and allied sciences. JAPS publishes manuscripts (Original research and review articles Mini-reviews, Short communication) on original work, either experimental or theoretical in the following areas; Pharmaceutics & Biopharmaceutics Novel & Targeted Drug Delivery Nanotechnology & Nanomedicine Pharmaceutical Chemistry Pharmacognosy & Ethnobotany Phytochemistry Pharmacology & Toxicology Pharmaceutical Biotechnology & Microbiology Pharmacy practice & Hospital Pharmacy Pharmacogenomics Pharmacovigilance Natural Product Research Drug Regulatory Affairs Case Study & Full clinical trials Biomaterials & Bioactive polymers Analytical Chemistry Physical Pharmacy.