Rafael Ponikvar MD, Joze Drinovec MD, PhD, Janez Varl MD, Andrej Bren MD, Radoslav Kveder MD
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Adsorption and desorption of proteins on plasmafilter membrane and its effect on macromolecular sieving coefficient
The purpose of this study was to find out the influence of adsorption and desorption of plasma proteins on the sieving coefficient during membrane plasma exchange. Adsorption and desorption of plasma proteins on plasmafilter membrane was an important feature in the study. It was more intensive with proteins with higher molecular weight (for IgG, α-2 macroglobulin, and IgM) and was not important with albumin. Sieving coefficients for IgG, α-2 macroglobulin, and IgM were unexpectedly high, while that of albumin remained within normal limits.
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