钌(II)三噻吩环壬烷5-(2-羟基苯基)-3-[(4-甲氧基苯基)吡唑]，一种易于合成且对PC-3和MDA-MB-231细胞具有高细胞毒性的配合物

Complex Metals Pub Date : 2014-03-14 DOI:10.1080/2164232X.2013.873992

J. Marques, Vera L. M. Silva, Artur M. S. Silva, Mario Monteiro Marques, S. Braga

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引用次数: 8

摘要

钌(II)配合物[Ru([9]aneS 3)(phpz)Cl 2] (1) ([9]aneS 3=三噻唑环壬烷，phpz=5-(2-羟基苯基)-3-[(4-甲氧基苯基)吡唑])通过[Ru([9]aneS 3)(DMSO)Cl 2]与一个等效的配体phpz反应，很容易分离得到。结合MS, FT-IR和溶液NMR研究(1- d和2-D)确定了配合物1的分子式，其中phpz通过简单取代前驱体的离去基DMSO以单齿模式与Ru(II)坐标。通过对人前列腺细胞(PC-3)和乳腺癌细胞(MDA-MB-231)的半最大生长抑制，研究了1的体外细胞毒特性。

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Ru(II) trithiacyclononane 5-(2-hydroxyphenyl)-3-[(4-methoxystyryl)pyrazole], a complex with facile synthesis and high cytotoxicity against PC-3 and MDA-MB-231 cells

The ruthenium(II) complex [Ru([9]aneS 3)(phpz)Cl 2] (1) ([9]aneS 3=trithiacyclononane, phpz=5-(2- hydroxyphenyl)-3-[(4-methoxystyryl)pyrazole]) was readily isolated by reacting [Ru([9]aneS 3)(DMSO)Cl 2] with one equivalent of the ligand phpz. A combination of MS, FT–IR and solution NMR studies (1-D and 2-D) was employed to determine the structural formula of the complex 1, in which phpz coordinates in a monodentate mode to Ru(II) by a simple replacement of the leaving group DMSO of the precursor. The cytotoxic properties of 1 in vitro were investigated by determination of the half-maximal growth inhibition on the human prostate (PC-3) and breast cancer cells (MDA-MB-231).

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Complex Metals

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