温度对微晶胆固醇生长速率的影响。2

Journal of the American Pharmaceutical Association. American Pharmaceutical Association Pub Date : 2006-09-27 DOI:10.1002/JPS.3030430607

A. P. Lemberger, T. Higuchi, L. W. Busse, D. Wurster

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摘要

研究了室温和高温热老化对冷冻干燥技术制备的亚微米胆固醇颗粒的影响。结果表明，热老化导致的比表面积下降速率与时效温度有关，并与Arrhenius方程的关系密切相关。理论方面的一个可能的机制操作的减少比表面积进行了讨论。

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Influence of temperature on the rate of growth of microcrystalline cholesterol. II.

Abstract The influence of thermal aging at room and elevated temperatures on submicron cholesterol particles prepared by the freeze‐drying technique has been investigated. It is shown that the rate of decrease in the specific surface area as a result of thermal aging is dependent upon the aging temperature and adheres closely to the relationship described by the Arrhenius equation. The theoretical aspects of a possible mechanism operative in the reduction of the specific surface area are discussed.

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Journal of the American Pharmaceutical Association. American Pharmaceutical Association

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