聚合物水凝胶辅助软骨再生方法治疗软骨损伤是一种新兴的治疗选择

Dodda Ravikalyan, Thukani Sathanantham Shanmugarajan, Uppuluri Varuna Naga Venkata Arjun
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引用次数: 0

摘要

软骨损伤是软骨结构的物理破坏,导致体液流失和个体疼痛。尽早诊断各种软骨缺损并发症对促进愈合至关重要。此外,为了加快软骨缺损的愈合过程,组织工程材料应该具有几个关键特性,包括理想的孔隙度和最小的细胞毒性。聚合物水凝胶支架的主要特点是提供湿润的环境,加速软骨修复和良好的生物相容性。大多数情况下,生物相容性聚合物和掺入剂(如干细胞、药物分子和生物活性剂)表现出协同效应,导致非常高的治疗指标。本文综述了软骨修复的阶段、用于软骨组织再生的天然和合成聚合物负载水凝胶的类型,以及干细胞负载水凝胶在软骨组织工程概念中的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Polymeric hydrogel-assisted chondro regenerative approaches towards cartilage injury therapy an emerging treatment option
An injury to the cartilage is a physical disruption of the cartilage's architecture, resulting in fluid loss and pain to the individual. The earliest possible diagnosis of various cartilage defect complications is vital to facilitate healing. Moreover, to fasten the healing process of the cartilage defect, tissue-engineered materials should have several key characteristics, including ideal porosity, and minimal cytotoxicity. The primary characteristic of polymeric hydrogel scaffolds is that they offer a moist environment that accelerates the cartilage repair and good biocompatibility. Most often, biocompatible polymers and incorporated agents (such as stem cells, drug molecules, and bioactive agents) exhibit synergistic effects, resulting in very high therapeutic indexes. This review highlights the phases of cartilage repair, types of natural and synthetic Polymer loaded hydrogels used in Cartilage tissue regeneration, and the importance of the stem cells loaded hydrogel in cartilage tissue engineering concepts.
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