绿葛地叶浸剂的通便作用雄性小白鼠(小家鼠)

Birgitta Vania Rarasati
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引用次数: 0

摘要

摘要背景:格地植物(Abelmoschus manihot (L.))锦葵科的锦葵是一种植物,它的叶子被人们用来治疗便秘等几种疾病。目的:研究绿葛地叶冲剂的通便作用。在雄性白鼠身上。方法:本研究为实验研究。将小鼠分为5组,每组6只,第一组为阴性对照(CMC Na 0.5%),第2、3、4组灌胃绿葛地叶(Abelmoschus manhot, L.)。Medik)剂量分别为130、260和520 mg/kgBW,第5组为阳性对照(bisacodyl)。根据排便次数、粪便重量和粪便粘稠度测定通便活性。结果:520 mg/kgBW剂量的平均排便次数最高(7.17次),260 mg/kgBW剂量的平均排便重量最高(0.20次)。但总体上各组间无显著差异,排便次数和粪便重的p值分别为0.132和0.246。在粪便一致性方面,两组之间没有差异,不排便和硬粪便。结论:本研究认为,在6小时内多次给药后,各组之间没有明显的通便作用,因此绿葛地叶在社会上的通便作用还不能在实验室得到实证证明。关键词:葛地叶,马氏白毛鼠本品有通便、通便作用
本文章由计算机程序翻译,如有差异,请以英文原文为准。
LAXATIVE EFFECT OF GREEN GEDI LEAVES INFUSES (Abelmoschus manihot (L.) Medik) ON MALE WHITE MICE (Mus musculus)
Abstract. Background: Gedi plant (Abelmoschus manihot (L.) Medik) of the Malvaceae family is a plant which leaf is used by peoples for the treatment of several illnesses such as constipation. Purpose: To investigate the laxative activity of green gedi leaves infuses (Abelmoschus manihot (L.) Medik) on male white mice.Method: This study is an experimental study. Mice were divided in 5 groups of 6 animals each, first group as negative control (CMC Na 0.5%) while group 2, 3 and 4 were treated with green gedi leaves infuses (Abelmoschus manihot (L.) Medik) at doses of 130, 260 and 520 mg/kgBW, per as respectively and group 5 as positive control (bisacodyl). The laxative activity was determined based on the frequency of defecation, weight of feces and consistency of feces.Results: It is found that 520 mg/kgBW dose has the highest mean of defecating frequency (7.17) and 260 mg/kgBW dose has the highest mean of feces weight (0.20). Statically however, there is no significant difference between the groups overall with p value of 0.132 and 0.246 for defecating frequency and feces weight respectively. There is no difference between the groups in term of feces consistency with both not defecating and hard feces.Conclusion: The research concludes that there is no significant laxative activity between each groups after administration of several dosages in 6 hours on mice thus the use of green gedi leaves as laxative in society can not be proven empirically in the laboratory.Keywords: gedi leaf, Abelmoschus manihot (L.) Medik, laxative effect, constipation
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