E. Seguin, A. Elomri, P. Magiatis, A. Skaltsounis, L. Chao, F. Tillequin
{"title":"Calythropsin和Combretastatins相关六氧合查尔酮的合成、二聚化和生物活性","authors":"E. Seguin, A. Elomri, P. Magiatis, A. Skaltsounis, L. Chao, F. Tillequin","doi":"10.1080/10575630290010993","DOIUrl":null,"url":null,"abstract":"Five new hexaoxygenated chalcones and one new chalcone photodimer were synthesized and their cytotoxicity against leukemia cell line L-1210 was studied. The three more active compounds were tested for their activity on the inhibition and promotion of tubulin assembly and it was found that these chalcones do not interfere with the tubulin-microtubule system at cytotoxic concentrations, and therefore operate by some different mechanism of action.","PeriodicalId":18873,"journal":{"name":"Natural Product Letters","volume":"3 1","pages":"187 - 193"},"PeriodicalIF":0.0000,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"6","resultStr":"{\"title\":\"Synthesis, Dimerization, and Biological Activity of Hexaoxygenated Chalcones Related to Calythropsin and Combretastatins\",\"authors\":\"E. Seguin, A. Elomri, P. Magiatis, A. Skaltsounis, L. Chao, F. Tillequin\",\"doi\":\"10.1080/10575630290010993\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Five new hexaoxygenated chalcones and one new chalcone photodimer were synthesized and their cytotoxicity against leukemia cell line L-1210 was studied. The three more active compounds were tested for their activity on the inhibition and promotion of tubulin assembly and it was found that these chalcones do not interfere with the tubulin-microtubule system at cytotoxic concentrations, and therefore operate by some different mechanism of action.\",\"PeriodicalId\":18873,\"journal\":{\"name\":\"Natural Product Letters\",\"volume\":\"3 1\",\"pages\":\"187 - 193\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2002-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Natural Product Letters\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/10575630290010993\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Letters","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/10575630290010993","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Synthesis, Dimerization, and Biological Activity of Hexaoxygenated Chalcones Related to Calythropsin and Combretastatins
Five new hexaoxygenated chalcones and one new chalcone photodimer were synthesized and their cytotoxicity against leukemia cell line L-1210 was studied. The three more active compounds were tested for their activity on the inhibition and promotion of tubulin assembly and it was found that these chalcones do not interfere with the tubulin-microtubule system at cytotoxic concentrations, and therefore operate by some different mechanism of action.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
