Calythropsin和Combretastatins相关六氧合查尔酮的合成、二聚化和生物活性

Natural Product Letters Pub Date : 2002-01-01 DOI:10.1080/10575630290010993

E. Seguin, A. Elomri, P. Magiatis, A. Skaltsounis, L. Chao, F. Tillequin

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引用次数: 6

摘要

合成了5个新的六氧合查尔酮和1个新的查尔酮光二聚体，并研究了它们对白血病L-1210细胞的细胞毒性。另外三种活性化合物对微管蛋白组装的抑制和促进活性进行了测试，发现这些查尔酮在细胞毒性浓度下不干扰微管-微管系统，因此通过一些不同的作用机制起作用。

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Synthesis, Dimerization, and Biological Activity of Hexaoxygenated Chalcones Related to Calythropsin and Combretastatins

Five new hexaoxygenated chalcones and one new chalcone photodimer were synthesized and their cytotoxicity against leukemia cell line L-1210 was studied. The three more active compounds were tested for their activity on the inhibition and promotion of tubulin assembly and it was found that these chalcones do not interfere with the tubulin-microtubule system at cytotoxic concentrations, and therefore operate by some different mechanism of action.

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来源期刊

Natural Product Letters

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