乙醇提取物的毒性研究大鼠排气

IF 2 4区 医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE
Yi Yan , Zhao Yong , Li Chunying , Zhang Yushi , Bin Yang , Yuan Yalan , Wang Lianmei , Pan Chen , Liang Aihua
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引用次数: 2

摘要

目的评价欧氧苄氨苄的安全性。Wistar大鼠连续用药26周。METHODSOroxylumindicum (l)分别以54、225和450 mg•kg•d - 1的剂量灌胃给雄性和雌性大鼠,每天1次。给药13周和26周后处死大鼠。给药26周后,各组均有部分大鼠恢复4周。分别于给药13周、26周和康复4周时进行血液学、泌尿学、血液生化和组织形态学等系统检查。结果对大鼠一般状态、体重、食量、尿指数及组织形态学检查均无不良反应。虽然在给药过程中,部分提取物组大鼠红细胞计数(RBC)、白细胞计数(WBC)、血红蛋白(HGB)、红细胞压差(HCT)、血钾铁(K - iron)下降,葡萄糖(GLU)、甘油三酯(TG)、丙氨酸转氨酶(ALT)、血尿素氮(BUN)等生化指标升高,但上述指标均在正常范围内,停药4周后均恢复到基线水平。结论:复方白藜芦醇(L.)在本研究中,高达450 mg/kg(相当于临床剂量的75倍)的排气提取物杠杆对两性都有良好的耐受性,在给药期间没有明显的毒性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Toxicity study of ethanol extract from Oroxylumindicum (L.) Vent in rats

OBJECTIVE

To evaluate the safety of Oroxylumindicum(L.) Vent extract administered for 26 weeks in Wistar rats.

METHODS

Oroxylumindicum (L.) Vent extract was administrated to male and female rats by gavage once daily at doses of 54, 225, and450 mg • kg−1 • d−1. The rats were sacrificed after administration for13 weeks and 26 weeks. Part of the rats in each group were allowed to recover for 4 weeks after 26-week administration. Systematic examinations including haematology, urology, blood biochemistry and histomorphology were performed at the end of 13, 26 weeks of administration and 4 weeks of recovery.

RESULTS

No treatment related adverse effect shappened on rats'general status, body weight, food consumption, urinary index and histomorphology examination. Although during the administration, in some rats of extract's groups, the value of Red blood cell count (RBC), white blood cell counts (WBC), hemoglobin (HGB), haematocrit (HCT) and K iron were decreased, and biochemistry index, such as glucose (GLU), triglyceride (TG), alanine transaminase (ALT) and blood urea nitrogen(BUN) were increased, the above parameters were within the normal ranges and all returned to baseline after the drug stopping for 4 weeks.

CONCLUSION

The administration of Oroxylumindicum(L.) Vent extractat levers up to 450 mg/kg (equals to 75 times of clinical dose) is well tolerated-for both genders without significant toxicity within the administration duration in this study.

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来源期刊
Journal of Traditional Chinese Medicine
Journal of Traditional Chinese Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-
CiteScore
2.40
自引率
3.80%
发文量
32269
审稿时长
2 months
期刊介绍: Journal of Traditional Chinese Medicine(JTCM) is devoted to clinical and theortical research on the use of acupuncture and Oriental medicine. The main columns include Clinical Observations, Basic Investigations, Reviews, Questions and Answers, an Expert''s Forum, and Discussions of Clinical Cases. Its key topics include acupuncture and electro-acupuncture, herbal medicine, homeopathy, masseotherapy, mind-body therapies, palliative care, and other CAM therapies.
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