胃肠道表现作为诊断新冠肺炎儿童病例的早期症状

J. Robinson, I. Banerjee, Alexandra Leclézio
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摘要

背景:在新冠肺炎大流行的国际形势下,多个国家正在与SARS-CoV-2病毒感染的各种浪潮作斗争,全球有数百万人感染。COVID-19病例最初涉及免疫功能低下和老年人。由于该病毒在全球感染了数百万人,病例的人口结构发生了变化,更多的儿童受到感染;年轻人感染人数的增加导致了新的症状,改变了年轻人的疾病表现和表现。与成人COVID-19的严重症状相比,儿童出现的症状更微不足道。大多数儿童出现轻微症状或无症状。这与症状严重且入院率较高的成人形成鲜明对比。在小儿COVID-19病例中,一个非常重要且现在发病率很高的迹象是胃肠道。由于ACE2受体的存在,该病毒对GIT具有趋向性,这有助于病毒进入细胞。结论:现在可以确定GIT症状是新发现的多系统炎症综合征(MIS-C)的一部分,该综合征是COVID-19感染的结果或表现。正确准确诊断这种病例的先天困难在于其症状与肠胃炎和急性腹部病变非常相似。因此,医生需要了解COVID-19感染在儿童中的各种表现形式,以便更好地诊断和隔离病例。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Gastrointestinal manifestations as early symptoms to diagnose COVID-19 paediatric cases
Background: The international situation surrounding the COVID-19 pandemic is seeing multiple countries battle various waves of the SARS-CoV-2 virus infections, with millions of individuals being infected globally. COVID-19 cases initially involved the immuno-compromised and elderly. As the virus has infected millions globally, the demographic profile of cases has shifted with more children being infected; this increase in younger individuals contracting the infection has resulted in new symptoms with altered manifestations and presentations of the disease in the young. In comparison to the severe symptoms of COVID-19 in adults children present with a more trivial group of symptoms. The majority of children develop mild symptoms or remain asymptomatic. This is in stark contrast to adults who have a higher admission rate with severe symptoms. A sign of great importance and now incidence in pediatric cases with COVID-19 is that of the gastrointestinal tract. The virus has a tropism for the GIT due to the presence of ACE2 receptors, which facilitate the entry of the virus into the cell. Conclusion: It is now established that the GIT symptoms form part of a newly recognized multisystem inflammatory syndrome (MIS-C) which occurs as a result and or manifestation of the COVID-19 infection. The innate difficulty in correctly and accurately diagnosing such a case is that the symptoms very close mimic gastroenteritis and acute abdominal pathologies. Therefore, physicians need to be aware of the various manners in which the COVID-19 infection manifests itself in children to diagnose better and isolate the cases. 
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