利用矢量形式分析生物组装中的疏水和电驱动力。

IF 7.2 2区生物学 Q1 BIOPHYSICS

Quarterly Reviews of Biophysics Pub Date : 2022-04-11 DOI:10.1017/S0033583522000038

Angel Mozo-Villarías, Juan A Cedano, Enrique Querol

引用次数: 0

摘要

疏水力不仅在蛋白质的三维结构构象中起着至关重要的作用，而且在dna -蛋白质复合物的形成中也起着至关重要的作用。在大分子结合的三级和四级结构中，电场也起着重要的作用。有时，疏水和电相互作用叠加在一起，形成这些结构，但在大多数情况下，它们的作用方向相反。这一事实，以及与不同范围的整体相互作用，提供了一种微妙的平衡，也通过需要遵守空间障碍和几何挫折效应来调节。本文主要介绍了利用疏水偶极矩和电偶极矩矢量来描述生物大分子结构的相互作用。虽然在文献中描述了电偶极矩和疏水矩的不同定义，但在生物组装中获得的结果证明了生物膜模型的原理。根据这个模型，我们的团队假设，生物大分子倾向于通过排列它们的疏水时刻以类似于膜中的磷脂的方式结合。封闭和开放结构的例子被用来评估我们模型的可预测性。我们寻求我们的结果与当前文献中描述的结果一致。回顾以使用这种形式对未来可能的预测作为结束。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Quarterly Reviews of Biophysics 生物-生物物理

CiteScore

12.90

自引率

1.60%

发文量

期刊介绍： Quarterly Reviews of Biophysics covers the field of experimental and computational biophysics. Experimental biophysics span across different physics-based measurements such as optical microscopy, super-resolution imaging, electron microscopy, X-ray and neutron diffraction, spectroscopy, calorimetry, thermodynamics and their integrated uses. Computational biophysics includes theory, simulations, bioinformatics and system analysis. These biophysical methodologies are used to discover the structure, function and physiology of biological systems in varying complexities from cells, organelles, membranes, protein-nucleic acid complexes, molecular machines to molecules. The majority of reviews published are invited from authors who have made significant contributions to the field, who give critical, readable and sometimes controversial accounts of recent progress and problems in their specialty. The journal has long-standing, worldwide reputation, demonstrated by its high ranking in the ISI Science Citation Index, as a forum for general and specialized communication between biophysicists working in different areas. Thematic issues are occasionally published.