药物相关的唾液腺改变-风险评估

Rooban Thavarajah Prof, Elizabeth Joshua Prof, U. R. Prof, Kannan Ranganathan Prof
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摘要

药物相关性唾液腺改变(MASGA)是与许多常见药物相关的一组常见不良事件(AE)。有一些关于药物治疗导致MASGA风险的报道。材料与方法采用全数据库方法,在美国食品药品监督管理局不良事件报告系统(FAERS)中检索MASGA。如药物警戒研究中所述,对常见改变和相关药物进行报告优势比评估。结果在所考虑的时间段内,FAERs数据库中报告的AE共有16996785例。其中68624例与MASGA相关,其中口干和多分泌物最为常见。抗精神病药物以氯氮平为主,ROR为58.04,其次是氟哌啶醇(25.29)。在导致SG增大的药物中,碘化钾(1335.32)和氧苯丁酮(696.58)的ROR最高。氟哌啶醇和依诺肝素钠的高ROR对唾液改变的非特异性描述(14.22)。总结与结论引起MASGA的药物比例为。慢性药物,例如治疗非传染性疾病、生活方式疾病和已知会导致MASGA的精神药物的药物。【关键词】唾液改变,口干,唾液腺增大,不良事件,药物警戒
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Medication Associated Salivary Gland Alterations– Assessment of risk
Brief Background Medication Associated Salivary Gland Alterations (MASGA) are a common set of adverse events (AE) associated with many common medications. There are a few reports of the risk of MASGA with medication. Materials and Methods Using whole database approach, the Food and Drug Administration Adverse Event Reporting System (FAERS) of the United States of America was searched for MASGA. Common alterations and drugs associated were assessed for the Reporting Odds Ratio, as mentioned in pharmacovigilance researches. Results In the time phase considered, there were in all 16996785 AE reported in the FAERs database. Of this 68624 were related to MASGA with Dry Mouth and hypersecretion being most common. Anti-psychotic drugs predominated the hypersecretion spectrum with clozapine having a ROR of 58.04 followed by Haloperidol (25.29). Among the drugs that caused SG enlargement, potassium iodide (1335.32) and Oxyphenbutazone (696.58) had the highest ROR. Non-specific description of altered saliva was seen with high ROR in haloperidol and enoxaparin sodium (14.22). Summary and Conclusions Odds Ratio of drugs causing MASGA are. chronic medication such as those given for non-communicable, life style diseases and psychiatric medications known to cause MASGA. Key Words Salivary Alterations, Xerostomia, Salivary gland enlargement, Adverse Events, Pharmacovigilance
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