多参数MRI评价保乳术后早期三阴性乳腺癌疑似乳腺病变

IF 1.6 Q4 ONCOLOGY
L. Sad, Naglaa Lofty Dabees, Dareen Abd El-Aziz Mohamed, A. Tageldin, S. Younis
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引用次数: 0

摘要

背景三阴性乳腺癌(TNBC)的局部复发率可高达12%。早期TNBC的标准治疗方法是保乳手术(BCS),然后是术后放疗加或不加化疗。然而,放射治疗后疾病局部复发的检测是一个主要问题。目的本研究的目的是探讨动态和功能性磁共振成像(MRI)在BCS和放疗伴/不伴化疗后随访中的作用,以区分局部复发和术后纤维化。患者和方法。本前瞻性研究在坦塔大学肿瘤科、放射科和病理科进行。该研究涉及50例早期TNBC患者,他们接受BCS治疗,随后进行放疗加/不加化疗。在随访期间通过超声x线摄影评估疑似病变。所有患者均接受MRI检查,包括常规序列、弥散加权成像(DWI)和动态对比后研究。结果10例确诊为复发性恶性病变。造影后均表现为不规则T1低密度病变,形态变化,扩散受限,阳性增强。8例显示III型曲线,2例显示II型曲线。所有8例患者的组织病理学检查结果与MRI一致。DWI-MRI与动态对比增强(DCE) MRI相结合,敏感性为100%,特异性为92.5%,阳性预测值为90.9%,阴性预测值为100%,准确率为98%。结论DWI-MRI与DCE-MRI联合应用对评价三阴癌患者BCS术后变化,再加/不加化疗放疗具有较高的诊断价值。试验注册。没有试验需要注册。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Assessment of Suspected Breast Lesions in Early-Stage Triple-Negative Breast Cancer during Follow-Up after Breast-Conserving Surgery Using Multiparametric MRI
Background The local recurrence rate of triple-negative breast cancer (TNBC) can be as high as 12%.The standard treatment for early-stage TNBC is breast-conserving surgery (BCS), followed by postoperative radiotherapy with or without chemotherapy. However, detection of the local recurrence of the disease after radiotherapy is a major issue. Objective The aim of this study was at investigating the role of dynamic and functional magnetic resonance imaging (MRI) during follow-up after BCS and radiotherapy with/without chemotherapy to differentiate between locoregional recurrence and postoperative fibrosis. Patients and Methods. This prospective study was conducted at the oncology, radiology, and pathology departments, Tanta University. It involved 50 patients with early-stage TNBC who were treated with BCS, followed by radiotherapy with/without chemotherapy. The suspected lesions were evaluated during the follow-up period by sonomammography. All patients were subjected to MRI, including conventional sequences, diffusion-weighted imaging (DWI), and dynamic postcontrast study. Results Ten cases were confirmed as recurrent malignant lesions. After contrast administration, they all exhibited irregular T1 hypodense lesions of variable morphology with diffusion restriction and positive enhancement. Eight cases displayed a type III curve, while two showed a type II curve. Histopathological assessment was consistent with the MRI findings in all eight cases. The combination of the data produced by DWI-MRI and dynamic contrast-enhanced (DCE) MRI resulted in 100%sensitivity, 92.5% specificity, 90.9% positive predictive value, 100% negative predictive value, and 98% accuracy. Conclusion Combination of DWI-MRI and DCE-MRI could have high diagnostic value for evaluating postoperative changes in patients with TNBC after BCS, followed by radiotherapy with/without chemotherapy. Trial Registrations. No trial to be registered.
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来源期刊
CiteScore
3.40
自引率
0.00%
发文量
25
审稿时长
19 weeks
期刊介绍: International Journal of Breast Cancer is a peer-reviewed, Open Access journal that provides a forum for scientists, clinicians, and health care professionals working in breast cancer research and management. The journal publishes original research articles, review articles, and clinical studies related to molecular pathology, genomics, genetic predisposition, screening and diagnosis, disease markers, drug sensitivity and resistance, as well as novel therapies, with a specific focus on molecular targeted agents and immune therapies.
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