Preparation & evaluation of paracetamol solid lipid nanoparticles by hot homogenization method

The solid lipid nanoparticles (SLNs) are sub-micron colloidal carriers (50-100nm) which are composed of physiological lipid dispersed in water or in an aqueous surfactant solution.1 SLNs are colloidal drug carrier combines the advantages of polymeric nanoparticles, fat emulsion and liposomes simultaneously and avoiding some of their disadvantages.2 To overcome the disadvantages associated with the liquid state of the oil droplets, the liquid lipid was replaced by a solid lipid which eventually transformed into solid lipid nanoparticles.3